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  1. Focal Adhesion Kinase as a Potential Target in AML and MDS

    ... that high FAK expression was associated with unfavorable cytogenetics (P = 2 x 10-4) and relapse (P = 0.02) in AML. FAK expression ...

    Research Article last updated 03/22/2017 - 10:20am.

  2. Promising news for older AML patients

    ... CR/CRi rate was 60% among patients with poor-risk cytogenetics and 78% among patients with intermediate-risk disease. In ...

    Article last updated 07/19/2017 - 11:19am.

  3. Outcome of patients treated for myelodysplastic syndromes without deletion 5q after failure of lenalidomide therapy

    ... of LEN was 43 months. In multivariate analysis, adverse cytogenetics , excess of blasts at the initiation of LEN, and the ...

    Research Article last updated 02/21/2017 - 9:43am.

  4. Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

    ... MDS continue to evolve, based on morphology , cytogenetics , and the presence of cytopenias. More accurate classification ...

    Research Article last updated 02/01/2017 - 9:01am.

  5. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... a.  18-81 years of age b.  MDS classification and cytogenetics confirmed within 8 weeks prior to or during screening as ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  6. The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

    ... including 17p abnormalities, monosomal and complex cytogenetics . TP53 mutations in these disorders portend rapid disease ...

    Research Article last updated 01/26/2017 - 10:06am.

  7. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

    ... (N = 44) was 64 years (range 36-90), and 46% had poor cytogenetics . Median number of azacitidine cycles was six (1-6). No ...

    Research Article last updated 02/03/2017 - 10:05am.

  8. Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki

    ... cytogenetic abnormalities, IPSS karyotype, and IPSS-R cytogenetics were significantly associated with poor survival, and ...

    Research Article last updated 11/02/2016 - 9:24am.

  9. Myelodysplastic syndromes: pathophysiology, clinical and biological features

    ... clinical and cytological data, results of conventional cytogenetics and evolution after vitamin therapy. Knowledge more depth on ...

    Research Article last updated 04/29/2016 - 11:32am.

  10. Myelodysplastic Syndromes in Adolescent Young Adults: One Institution's Experience

    ... among patients with good, intermediate, and poor risk cytogenetics , respectively (P = .035). CONCLUSION: MDS is rare and ...

    Research Article last updated 09/19/2016 - 11:09am.