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  1. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... proportion of patients with early relapse had high-risk cytogenetics compared with patients with late relapse (P = .009). ... late relapse showed molecular differences not detectable by cytogenetics between the pre-HCT clones and the clones at relapse. These data ...

    Research Article last updated 06/03/2015 - 12:48pm.

  2. Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

    ... When parsed by VAF, TP53 VAF predicted for complex cytogenetics in both the training (P=0.001) and validation set (P<0.0001). ...

    Research Article last updated 12/08/2015 - 1:04pm.

  3. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge

    ... Analysis Workshop (n = 816), the Spanish Hematological Cytogenetics Working Group (n = 849), and the International Working Group on MDS Cytogenetics (n = 44) databases. Patients with primary MDS and ...

    Research Article last updated 07/28/2014 - 10:43am.

  4. Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine

    ... OS 12.4 months versus 23.7 months, p<10-4), abnormal cytogenetics (median OS 14.4 months vs 33 months, p=0.02) complex cytogenetics (median OS 12.7 months versus 23.7 months, p=0.0005), and a ...

    Research Article last updated 06/02/2014 - 11:17am.

  5. The Genetic Basis and Expanding Role of Molecular Analysis in the Diagnosis, Prognosis, and Therapeutic Design for Myelodysplastic Syndromes

    ... one or more hematopoietic lineages. Classical metaphase cytogenetics and judicious use of fluorescence in situ hybridization ... appreciation that includes histomorphology, metaphase cytogenetics, and directed molecular studies. In the present health-care ...

    Research Article last updated 02/04/2014 - 2:01pm.

  6. Cutting edge: flow cytometry in myelodysplastic syndromes

    ... syndromes (MDS), especially when cytomorphology and cytogenetics are inconclusive. Minimal requirements to analyze dysplasia ...

    Research Article last updated 08/06/2013 - 12:05pm.

  7. Improving the diagnosis and treatment of patients with myelodysplastic syndromes through a performance improvement initiative

    ... careful consideration of pathologic features and cytogenetics , and treatment options vary based on disease severity. A ...

    Research Article last updated 02/08/2013 - 7:53am.

  8. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... polymorphism (SNP) arrays, complementing routine cytogenetics . We hypothesized that clinically important cryptic clonal ... in 5/14 (36%) patients with normal/non-informative routine cytogenetics. In a subset of AA patients studied at presentation, persistent ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes

    ... patients with AML and MDS, including those with normal cytogenetics . DNA-level mutations in several of these genes including ...

    Research Article last updated 06/03/2015 - 11:09am.

  10. GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia

    ... CD4:CD8 ratios. Atypical megakaryocytes and abnormal cytogenetics were more common in GATA2 marrows. CD34+ cells were ... routine BM flow cytometry , morphology and cytogenetics, in patients who present with cytopenia (s), can identify ...

    Research Article last updated 11/25/2014 - 9:57am.