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  1. Cutting edge: flow cytometry in myelodysplastic syndromes

    ... syndromes (MDS), especially when cytomorphology and cytogenetics are inconclusive. Minimal requirements to analyze dysplasia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Improving the diagnosis and treatment of patients with myelodysplastic syndromes through a performance improvement initiative

    ... careful consideration of pathologic features and cytogenetics , and treatment options vary based on disease severity. A ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge

    ... Analysis Workshop (n = 816), the Spanish Hematological Cytogenetics Working Group (n = 849), and the International Working Group on MDS Cytogenetics (n = 44) databases. Patients with primary MDS and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... polymorphism (SNP) arrays, complementing routine cytogenetics . We hypothesized that clinically important cryptic clonal ... in 5/14 (36%) patients with normal/non-informative routine cytogenetics. In a subset of AA patients studied at presentation, persistent ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... proportion of patients with early relapse had high-risk cytogenetics compared with patients with late relapse (P = .009). ... late relapse showed molecular differences not detectable by cytogenetics between the pre-HCT clones and the clones at relapse. These data ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia

    ... CD4:CD8 ratios. Atypical megakaryocytes and abnormal cytogenetics were more common in GATA2 marrows. CD34+ cells were ... routine BM flow cytometry , morphology and cytogenetics, in patients who present with cytopenia (s), can identify ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

    ... When parsed by VAF, TP53 VAF predicted for complex cytogenetics in both the training (P=0.001) and validation set (P<0.0001). ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes

    ... patients with AML and MDS, including those with normal cytogenetics . DNA-level mutations in several of these genes including ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Response to azacitidine is independent of p53 expression in higher-risk myelodysplastic syndromes and secondary acute myeloid leukemia.

    ... patients were p53-positive and most had very poor risk cytogenetics with chromosome 5 aberrations and monosomal karyotypes. The ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution

    ... counts, lower lactate dehydrogenase levels, good-risk cytogenetics and mutations of DNMT3A, but inversely related to ASXL1 ...

    Research Article last updated 07/20/2018 - 5:15pm.