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  1. Focal Adhesion Kinase as a Potential Target in AML and MDS

    ... that high FAK expression was associated with unfavorable cytogenetics (P = 2 x 10-4) and relapse (P = 0.02) in AML. FAK expression ...

    Research Article last updated 03/22/2017 - 10:20am.

  2. Outcome of patients treated for myelodysplastic syndromes without deletion 5q after failure of lenalidomide therapy

    ... of LEN was 43 months. In multivariate analysis, adverse cytogenetics , excess of blasts at the initiation of LEN, and the ...

    Research Article last updated 02/21/2017 - 9:43am.

  3. Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes

    ... with this condition, have now been identified. Cytogenetics forms the cornerstone of the most widely adopted prognostic ... in MDS pathogenesis. Integration of molecular genetics and cytogenetics holds much promise for improving clinical care and outcomes for ...

    Research Article last updated 01/26/2017 - 11:01am.

  4. Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

    ... MDS continue to evolve, based on morphology , cytogenetics , and the presence of cytopenias. More accurate classification ...

    Research Article last updated 02/01/2017 - 9:01am.

  5. The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

    ... including 17p abnormalities, monosomal and complex cytogenetics . TP53 mutations in these disorders portend rapid disease ...

    Research Article last updated 01/26/2017 - 10:06am.

  6. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

    ... (N = 44) was 64 years (range 36-90), and 46% had poor cytogenetics . Median number of azacitidine cycles was six (1-6). No ...

    Research Article last updated 02/03/2017 - 10:05am.

  7. Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki

    ... cytogenetic abnormalities, IPSS karyotype, and IPSS-R cytogenetics were significantly associated with poor survival, and ...

    Research Article last updated 11/02/2016 - 9:24am.

  8. Myelodysplastic Syndromes in Adolescent Young Adults: One Institution's Experience

    ... among patients with good, intermediate, and poor risk cytogenetics , respectively (P = .035). CONCLUSION: MDS is rare and ...

    Research Article last updated 09/19/2016 - 11:09am.

  9. Myelodysplastic syndromes: pathophysiology, clinical and biological features

    ... clinical and cytological data, results of conventional cytogenetics and evolution after vitamin therapy. Knowledge more depth on ...

    Research Article last updated 04/29/2016 - 11:32am.

  10. Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

    ... When parsed by VAF, TP53 VAF predicted for complex cytogenetics in both the training (P=0.001) and validation set (P<0.0001). ...

    Research Article last updated 12/08/2015 - 1:04pm.