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  1. Types

    ... patients a score based on three factors: cytogenetics (changes in cell DNA) cytopenias (low blood cell counts) ... 2 3 4 Cytogenetics Very Good   Good   ...

    Topic section last updated 05/16/2018 - 11:26am.

  2. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... a.  18-81 years of age b.  MDS classification and cytogenetics confirmed within 8 weeks prior to or during screening as ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  3. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... complications as assessed by WES, SNP-A, and metaphase cytogenetics , and more frequent secondary MDS . The finding of ...

    Research Article last updated 10/23/2017 - 10:56am.

  4. Promising news for older AML patients

    ... CR/CRi rate was 60% among patients with poor-risk cytogenetics and 78% among patients with intermediate-risk disease. In ...

    Article last updated 07/19/2017 - 11:19am.

  5. Outcome of patients treated for myelodysplastic syndromes with 5q deletion after failure of lenalidomide therapy.

    ... progression after LEN failure, and unfavorable cytogenetics . Among the treatment strategies, we observed a relatively ...

    Research Article last updated 07/11/2017 - 10:11am.

  6. Focal Adhesion Kinase as a Potential Target in AML and MDS

    ... that high FAK expression was associated with unfavorable cytogenetics (P = 2 x 10-4) and relapse (P = 0.02) in AML. FAK expression ...

    Research Article last updated 03/22/2017 - 10:20am.

  7. Outcome of patients treated for myelodysplastic syndromes without deletion 5q after failure of lenalidomide therapy

    ... of LEN was 43 months. In multivariate analysis, adverse cytogenetics , excess of blasts at the initiation of LEN, and the ...

    Research Article last updated 02/21/2017 - 9:43am.

  8. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

    ... (N = 44) was 64 years (range 36-90), and 46% had poor cytogenetics . Median number of azacitidine cycles was six (1-6). No ...

    Research Article last updated 02/03/2017 - 10:05am.

  9. Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

    ... MDS continue to evolve, based on morphology , cytogenetics , and the presence of cytopenias. More accurate classification ...

    Research Article last updated 02/01/2017 - 9:01am.

  10. Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes

    ... with this condition, have now been identified. Cytogenetics forms the cornerstone of the most widely adopted prognostic ... in MDS pathogenesis. Integration of molecular genetics and cytogenetics holds much promise for improving clinical care and outcomes for ...

    Research Article last updated 01/26/2017 - 11:01am.