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  1. Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Hematologic Malignancies Undergoing Donor Peripheral Blood Stem Cell Transplant

    ... This phase II trial studies how well sirolimus, cyclosporine and mycophenolate mofetil works in preventing graft-vs-host ... Giving total-body irradiation together with sirolimus, cyclosporine, and mycophenolate mofetil before and after transplant may stop ...

    Clinical Trial last updated 04/28/2016 - 12:07pm.

  2. What are the side effects of cyclosporine?

    Cyclosporine is a drug that lowers your body's immune response. Cyclosporine is used along with antithymocyte globulin (ATG), another ... bone marrow failure diseases. If you are taking cyclosporine as part of your treatment regimen, your doctor should monitor you ...

    FAQ last updated 03/15/2016 - 11:48pm.

  3. Immunosuppressive Therapy

    ... include ATG ( antithymocyte globulin ) and cyclosporine . This therapy helps some MDS patients, especially those ... few weeks afterward to prevent or treat serum sickness. Cyclosporine How Cyclosporine Works Cyclosporine prevents ...

    Page last updated 01/20/2015 - 4:45pm.

  4. Katie Begin and her parents find that giving back is its own reward

    ... of horse ATG, augmented with prednisone and cyclosporine . She was transfusion-dependent with blood and platelets for 3 months. Katie had cyclosporine for about 9 months and switched to tacrolimus which she tolerated ...

    Patient Chronicle last updated 01/04/2017 - 11:12am.

  5. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine has been considered the first-line therapy. Up to 80% of ...

    Interview last updated 11/28/2016 - 2:58pm.

  6. My Son's Aplastic Anemia -- A Mother's Account

    ... treatment in April, 2014 and stayed on a full dose of cyclosporine for 7 months, at which point he started to taper off this drug. This process took 6 months, so his cyclosporine treatment lasted 13 months. Within a few months, the ...

    Patient Chronicle last updated 12/15/2016 - 11:21am.

  7. Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome

    ... 14, subjects will receive hATG, Methylprednisolone and Cyclosporine . From Day 15 until Day 30 (of the first month), subjects will continue treatment only with Methylprednisolone and Cyclosporine. Cyclosporine will continue daily through Month 6/Day 30 (M6/D30) ...

    Clinical Trial last updated 04/26/2016 - 11:45am.

  8. CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

    ... normal cells (called graft-versus-host disease). Giving cyclosporine and mycophenolate mofetil after the transplant may stop this ... immune suppression therapy with either tacrolimus or cyclosporine at the time of CD8+ memory T-cell infusion; prednisone ...

    Clinical Trial last updated 04/29/2016 - 12:36pm.

  9. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

    ... to IST with horse anti-thymocyte globulin (h-ATG) and cyclosporine . Despite various efforts to improve IST results, horse ATG plus cyclosporine is still the regimen with better outcomes and is thus the standard ...

    Research Review last updated 05/02/2016 - 9:13am.

  10. Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancers

    ... will receive immune modulating drugs sirolimus and cyclosporine to prevent GVHD. Objective: To determine the safety, ... that use low-intensity chemotherapy, sirolimus plus cyclosporine, and transplant booster with either Th2 cells or standard immune ...

    Clinical Trial last updated 04/28/2016 - 11:28am.