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  1. Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia

    ... Anti-thymocyte globulin (ATG) plus cyclosporine is effective in restoring hematopoiesis in severe ... disease, patients were randomized between rabbit ATG plus cyclosporine (n=27) vs. alemtuzumab (n=27); the response rate for alemtuzumab ...

    Research Article last updated 11/16/2011 - 1:57pm.

  2. A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG), cyclosporine, with or without G-CSF: a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation.

    ... treated with antithymocyte globulin (ATG) and cyclosporine (CSA). Between January 2002 and July 2008, 192 patients with ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... therapy with a horse anti-thymocyte globulin plus cyclosporine regimen from 2000 to 2008. RESULTS: The presence of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Aplastic anemia: first-line treatment by immunosuppression and sibling marrow transplantation.

    ... the combination of antithymocyte globulin and cyclosporine A for patients without a sibling donor and HLA ... cell source, and graft-versus-host diease prophylaxis using cyclosporine A and methotrexate. It is against these standard treatment ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia

    ... A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe ... a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy for severe aplastic anemia. DESIGN AND ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Paroxysmal nocturnal hemoglobinuria clones in children with acquired aplastic anemia: a multicentre study

    ... appearance of a GPI-negative population was observed at cyclosporine (CSA) tapering or AA relapse, a possible role of GPI-negative ...

    Research Article last updated 08/04/2014 - 8:16am.

  7. Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia

    ... known. We investigated standard horse ATG (h-ATG) plus cyclosporine (CsA) in patients who were refractory to initial ...

    Research Article last updated 02/04/2014 - 1:27pm.

  8. Aplastic anemia: what have we learned from animal models and from the clinic.

    ... as anti-thymocyte globulin (ATG) and the requirement of cyclosporine to maintain response; evidence of an immune system in disarray ...

    Research Article last updated 11/21/2013 - 11:26am.

  9. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... therapy (IST) with anti-thymocyte globulin and cyclosporine A which targets self-reactive T cells, or (2) matched sibling ...

    Research Article last updated 11/14/2013 - 11:18am.

  10. Immunological derangement in hypocellular myelodysplastic syndromes

    ... is the response to immunosuppression including mainly cyclosporine , anti-thymocyte globulin and/or cyclosporine, or alemtuzumab . Here we review all these immune ...

    Research Article last updated 05/22/2014 - 9:53am.