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  1. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

    ... PubMed Abstract:  "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does ... at long-term. One attempt to improve IST results is cyclophosphamide . It was first used in high dose (200 mg/kg) as an ...

    Research Review last updated 05/02/2016 - 9:13am.

  2. Even "Moderate" Dose Cyclophosphamide for Severe Aplastic Anemia Is Associated with Significant Toxicities and Does Not Prevent Relapse and Clonal Evolution

    ... investigators evaluated the use of “moderate” dose cyclophosphamide for severe aplastic anemia for patients who do not have a compatible donor.  In earlier studies, high dose cyclophosphamide (200mg/kg) had unacceptable toxicities (including death from ...

    Research Review last updated 05/02/2016 - 9:23am.

  3. Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis

    ... main purpose of this study is to assess the effects of cyclophosphamide (cytoxan) in the post transplant setting to prevent onset ... Hematopoeitic Cell Transplant (HCT) using post-transplant cyclophosphamide (cytoxan) for patients with human leukocyte antigen ( ...

    Clinical Trial last updated 04/27/2016 - 9:38am.

  4. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Sy

    ... when given together with fludarabine phosphate, cyclophosphamide , total-body irradiation, and donor bone marrow ... chemotherapy drugs, such as fludarabine phosphate and cyclophosphamide, and total-body irradiation before a donor bone marrow ...

    Clinical Trial last updated 04/28/2016 - 1:01pm.

  5. Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematologic Disease

    ... an umbilical cord blood transplant together with cyclophosphamide , fludarabine phosphate, and total-body irradiation ... hematologic disease. Giving chemotherapy , such as cyclophosphamide and fludarabine phosphate, and TBI before a donor umbilical ...

    Clinical Trial last updated 04/29/2016 - 1:56pm.

  6. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... when given together with fludarabine phosphate, cyclophosphamide , total-body irradiation, donor bone marrow transplant ... chemotherapy , such as fludarabine phosphate and cyclophosphamide, and total-body irradiation before a donor bone marrow ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.

  7. GVHD Prophylaxis With Post Transplant Cyclophosphamide for Patients With Renal Insufficiency Undergoing a Conventional 8/8 HLA-matched Related or Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplant

    ... and benefit of giving a type of chemotherapy - cyclophosphamide - after the transplant to prevent graft versus host ... Associated Drug(s):  Cyclophosphamide Gender:  ...

    Clinical Trial last updated 04/29/2016 - 12:40pm.

  8. Improved Outcome of Reduced Toxicity Fludarabine, Cyclophosphamide Plus Thymoglobulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of Two Multicenter Prospective Studies

    ... investigators. The hope was that by reducing the dose of cyclophosphamide , increasing the dose of fludarabine , and ... The first study enrolled 28 patients who received cyclophosphamide (50mg/kg x 4 days), fludarabine (30mg/m2 for 4 days), and ...

    Research Review last updated 05/02/2016 - 9:24am.

  9. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... This regimen, consisting of fludarabine , cyclophosphamide and low dose total body irradiation (TBI), is designed for ... Associated Drug(s):  Cyclophosphamide Fludarabine ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  10. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... 30 mg/M2 IV on days -6 to -2 Drug: Cyclophosphamide 14.5 mg/kg IV on days -6, -5, 3, 4 Other Name: ... Associated Drug(s):  Cyclophosphamide Fludarabine Mycophenolate ...

    Clinical Trial last updated 06/06/2016 - 2:42pm.