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  1. Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... rapidly among older adults. Modern post-transplant cyclophosphamide (PTCy) protocols with haploidentical (haplo) donors have ...

    Research Article last updated 11/14/2017 - 10:09am.

  2. Cyclophosphamide

    ... [TODO] This content is all filler.  Please replace. Cyclophosphamide ( INN ), also known as cytophosphane, is a medication ... forming intrastrand and interstrand DNA crosslinks . Cyclophosphamide is used to treat cancers , autoimmune disorders , and ...

    Drug last updated 03/24/2016 - 12:32pm.

  3. Haploidentical transplant in patients with myelodysplastic syndrome

    ... transplant and 102 patients received posttransplant cyclophosphamide (PT-CY) as graft-versus-host disease (GVHD) ...

    Research Article last updated 10/04/2017 - 9:19am.

  4. Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia

    ... Here, we employed post-transplantation high-dose cyclophosphamide in an effort to safely expand the donor pool in 16 ... antithymocyte globulin , fludarabine , low-dose cyclophosphamide, and total body irradiation. Post-transplantation cyclophosphamide 50 mg/kg/day i.v. on days +3 and +4 was administered for ...

    Research Article last updated 01/24/2017 - 10:04am.

  5. Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconi anemia undergoing allogeneic hematopoietic stem cell transplantation.

    ... regimen consisting of fludarabine (F-araA) and cyclophosphamide (Cy) is associated with improved outcome in young patients ...

    Research Article last updated 05/22/2017 - 10:32am.

  6. High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia

    ... OBJECTIVE: Use of high-dose cyclophosphamide without hematopoietic stem cell transplant to ... than 22 years of age treated with 29 courses of high-dose cyclophosphamide as the sole form of immunosuppression. STUDY DESIGN: ...

    Research Article last updated 11/01/2016 - 1:49pm.

  7. A randomized comparison of cyclophosphamide vs. reduced dose cyclophosphamide plus fludarabine for allogeneic hematopoietic cell transplantation in patients with aplastic anemia and hypoplastic myelodysplastic syndrome.

    ... Recently, a less toxic regimen comprising reduced cyclophosphamide (Cy), fludarabine , and anti-thymocyte globulin ...

    Research Article last updated 05/11/2012 - 2:04pm.

  8. High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia

    ... OBJECTIVE: Use of high-dose cyclophosphamide without hematopoietic stem cell transplant to ... than 22 years of age treated with 29 courses of high-dose cyclophosphamide as the sole form of immunosuppression. STUDY DESIGN: ...

    Research Article last updated 08/15/2016 - 11:49am.

  9. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution.

    ... line therapy of aplastic anemia with high dose cyclophosphamide causes toxicity and increased short-term mortality. We investigated cyclophosphamide at a lower "moderate" dose, in combination with aggressive ...

    Research Article last updated 10/07/2014 - 8:33am.

  10. Clinical applications of haploidentical hematopoietic stem cell transplantation in severe aplastic anemia

    ... cells . The conditioning regimen before HSCT included cyclophosphamide , fludarabine , pig anti-human lymphocyte ...

    Research Article last updated 02/03/2017 - 9:36am.