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  1. PNH: Causes

    ... of proteins that protect normal red blood cells from the complement system. So they may be attacked and destroyed by the complement system ...

    Page last updated 06/29/2015 - 8:44am.

  2. Soliris

    ... Agency (EMEA) to treat PNH. It works by making your complement system less active. Benefits of Soliris Soliris has many benefits. ...

    Page last updated 06/29/2015 - 9:07am.

  3. PNH: Diagnosis

    ... Type I cells: These cells respond in a healthy way to the complement system. They are normal cells. PNH II cells, or Type II cells: These cells ...

    Page last updated 01/20/2015 - 4:48pm.

  4. Prednisone

    ... hemolysis caused by PNH. It may make the complement system less active. It may also increase counts of white blood cells and ...

    Page last updated 01/20/2015 - 4:57pm.

  5. Special Issues for People with PNH

    ... risky for people with PNH because surgery: Makes the complement system more active, which can cause hemolysis Increases the risk of ...

    Page last updated 01/20/2015 - 4:59pm.

  6. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and ... opsonization of PNH erythrocytes in an established in vitro system. Both compounds demonstrated dose-dependent inhibition of hemolysis ...

    Research Article last updated 03/06/2014 - 11:17am.

  7. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 03/05/2013 - 9:38am.

  8. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 10/02/2012 - 9:57am.

  9. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... The recent availability of eculizumab as the first complement inhibitor renewed the interest for complement-mediated damage in ... our understanding of different steps of the complement system in human diseases, as well as their modulation by current ...

    Research Article last updated 10/02/2012 - 10:00am.

  10. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... to the pathogenesis of thrombosis in PNH. The terminal complement inhibitor, eculizumab, induced a significant and sustained decrease in the activation of both the plasma hemostatic system and the vascular endothelium, likely contributing to the protective ...

    Research Article last updated 10/11/2011 - 5:58pm.