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  1. Patrizia Ricci, PhD

    ... , and thrombosis . Recently, the availability of the complement inhibitor eculizumab has dramatically improved the treatment ... of a novel class of peptides which target the complement system at the level of C3, the key component of the complement.  The ...

    Grant Recipient last updated 09/14/2016 - 2:42pm.

  2. AK579 (COBALT)

    ... of the Investigator, would benefit from treatment with a complement C5 inhibitor  Aged 18 and above. No upper age limit Males ... Any other drug acting directly on the complement system is prohibited Chemotherapeutic agents within 3 months of ...

    Clinical Trial last updated 09/14/2016 - 10:39am.

  3. Chao-Yie Yang, MD, PhD

    ... Discovery of small molecule complement inhibitors as the treatment for PNH ... inhibits C3, a key component of the complement activation system responsible for the cause of PNH, and the use of AMY-101 is a new ...

    Grant Recipient last updated 08/09/2016 - 1:02pm.

  4. Diagnosis

    ... cells are normal. They respond in a healthy way to the complement system . PNH II cells, or Type II cells:  These cells are partially ...

    Topic section last updated 03/10/2016 - 11:04pm.

  5. Youmna Kfoury, PhD

    ... libraries, we used the Clontech SMARTer Ultra low input RNA system which were then sequenced on Illumina Hiseq2000 instrument, resulting in ... the co-culture. In the case of up regulated genes we will complement our CRISPR based knock out with an over expression strategy. ...

    Grant Recipient last updated 12/15/2016 - 12:56pm.

  6. Causes

    ... protect normal red blood cells from a part of your immune system called the complement system. These PNH cells are attacked and destroyed by the ...

    Topic section last updated 03/29/2016 - 6:15pm.

  7. Symptoms

    ... apart of red blood cells. Hemolysis happens when the complement system , a part of your body’s immune system, becomes more active and ...

    Topic section last updated 03/29/2016 - 6:18pm.

  8. Eculizumab

    ... Eculizumab causes the complement system , a part of your immune system, to be less active. By doing this it ...

    Drug last updated 03/24/2016 - 12:32pm.

  9. PNH - Treatment (OLD)

    ... growth factor to increase your count and improve your immune system. The most common ones are: G-CSF ( granulocyte ... hemolysis caused by PNH. It may make the complement system less active. It may also increase counts of white blood ...

    Topic section last updated 03/10/2016 - 11:09pm.

  10. Prednisone

    ... hemolysis caused by PNH. It may make the complement system less active. Prednisone does not stop all hemolysis, ...

    Topic section last updated 03/10/2016 - 11:27pm.