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  1. PNH - Basics

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Topic section last updated 04/05/2016 - 4:02pm.

  2. Clone of Patients

    ...

    Page last updated 03/14/2016 - 6:05pm.

  3. AK579 (COBALT)

    ... of the Investigator, would benefit from treatment with a complement C5 inhibitor  Aged 18 and above. No upper age limit Males ... Any other drug acting directly on the complement system is prohibited Chemotherapeutic agents within 3 months of ...

    Clinical Trial last updated 09/14/2016 - 10:39am.

  4. Youmna Kfoury, PhD

    ... libraries, we used the Clontech SMARTer Ultra low input RNA system which were then sequenced on Illumina Hiseq2000 instrument, resulting in ... the co-culture. In the case of up regulated genes we will complement our CRISPR based knock out with an over expression strategy. ...

    Grant Recipient last updated 12/15/2016 - 12:56pm.

  5. Chao-Yie Yang, MD, PhD

    ... Discovery of small molecule complement inhibitors as the treatment for PNH ... inhibits C3, a key component of the complement activation system responsible for the cause of PNH, and the use of AMY-101 is a new ...

    Grant Recipient last updated 08/09/2016 - 1:02pm.

  6. Diagnosis

    ... cells are normal. They respond in a healthy way to the complement system . PNH II cells, or Type II cells:  These cells are partially ...

    Topic section last updated 03/10/2016 - 11:04pm.

  7. Causes

    ... protect normal red blood cells from a part of your immune system called the complement system. These PNH cells are attacked and destroyed by the ...

    Topic section last updated 03/29/2016 - 6:15pm.

  8. Symptoms

    ... apart of red blood cells. Hemolysis happens when the complement system , a part of your body’s immune system, becomes more active and ...

    Topic section last updated 03/29/2016 - 6:18pm.

  9. Eculizumab

    ... Eculizumab causes the complement system , a part of your immune system, to be less active. By doing this it ...

    Drug last updated 03/24/2016 - 12:32pm.

  10. PNH - Treatment (OLD)

    ... growth factor to increase your count and improve your immune system. The most common ones are: G-CSF ( granulocyte ... hemolysis caused by PNH. It may make the complement system less active. It may also increase counts of white blood ...

    Topic section last updated 03/10/2016 - 11:09pm.