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  1. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and ... opsonization of PNH erythrocytes in an established in vitro system. Both compounds demonstrated dose-dependent inhibition of hemolysis ...

    Research Article last updated 03/06/2014 - 11:17am.

  2. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... The recent availability of eculizumab as the first complement inhibitor renewed the interest for complement-mediated damage in ... our understanding of different steps of the complement system in human diseases, as well as their modulation by current ...

    Research Article last updated 10/02/2012 - 10:00am.

  3. Announcing AAMDSIF 2016 Research Awards

    ... attach to blood cells and protect them from destruction by complement, part our immune system. The result of this deficiency is a breakdown of red cells. If large ...

    Article last updated 06/09/2016 - 12:45pm.

  4. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... to the pathogenesis of thrombosis in PNH. The terminal complement inhibitor, eculizumab, induced a significant and sustained decrease in the activation of both the plasma hemostatic system and the vascular endothelium, likely contributing to the protective ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Alina Dulau Florea, MD

    ... attach to blood cells and protect them from destruction by complement, part our immune system. The result of this deficiency is a breakdown of red cells. If large ...

    Grant Recipient last updated 06/08/2017 - 10:39am.

  6. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... normally protect red blood cells from destruction by the complement system . The proteins in the complement system normally fight foreign ...

    Research Review last updated 05/02/2016 - 9:21am.

  7. Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

    ... this will be because eculizumab only partially blocks the complement proteins. It turns out that there are two key complement proteins, ... they both work at an early stage in the complement system , these compounds might prevent both types of hemolysis (breakdown in ...

    Research Review last updated 05/02/2016 - 9:25am.

  8. Interviews with the Experts: Hemolysis in PNH and Beyond

    ... within the blood vessels and is typically induced by the complement system , which is an integral part of the immune system. The purpose of the ...

    Interview last updated 08/31/2016 - 8:40am.

  9. PNH - Basics

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Topic section last updated 04/05/2016 - 4:02pm.

  10. Understanding the Compliment System and the PNH Clone

    ... Webinar The complement system is a group of proteins in the blood. They help support (complement) ...

    LMS Item last updated 06/10/2016 - 1:24pm.