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  1. Special Precautions

    ... be risky for people with PNH because it: Makes the complement system more active, which can cause hemolysis Increases the ...

    Topic section last updated 09/08/2017 - 12:34pm.

  2. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... diseases of excess activation of the alternative pathway of complement that are treated with eculizumab , a humanized monoclonal ... dysregulation and validating the modified Ham test as a system for preclinical drug development for atypical hemolytic uremic syndrome. ...

    Research Article last updated 11/28/2016 - 11:42am.

  3. Interviews with the Experts: The Complement System in PNH

    ... association it has with PNH, what is the function of the complement system ? The complement system initially got that name because it ...

    Interview last updated 08/31/2016 - 8:39am.

  4. Local TV covers AAMDSIF Peer Support Networker

    ...   PNH is an acquired rare disorder characterized the complement system destructing red blood cells to early. Red blood cells are missing ...

    Article last updated 11/28/2016 - 3:21pm.

  5. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... proteins involved in the regulation of the complement system renders PNH erythrocytes susceptible to complement-mediated lysis. Clinical manifestations include thromboembolic ...

    Research Article last updated 09/13/2016 - 1:53pm.

  6. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Page last updated 02/27/2017 - 7:37am.

  7. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 03/05/2013 - 9:38am.

  8. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 10/02/2012 - 9:57am.

  9. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and ... opsonization of PNH erythrocytes in an established in vitro system. Both compounds demonstrated dose-dependent inhibition of hemolysis ...

    Research Article last updated 03/06/2014 - 11:17am.

  10. Alina Dulau Florea, MD

    ... attach to blood cells and protect them from destruction by complement, part our immune system. The result of this deficiency is a breakdown of red cells. If large ...

    Grant Recipient last updated 06/08/2017 - 10:39am.