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  1. Alina Dulau Florea, MD

    ... attach to blood cells and protect them from destruction by complement, part our immune system. The result of this deficiency is a breakdown of red cells. If large ...

    Grant Recipient last updated 01/12/2018 - 9:50am.

  2. Foundation Update - September 2016

    ... August webinars: •  Understanding the Complement System and the PNH Clone • Bone Marrow Transplantation for ...

    Article last updated 10/09/2017 - 2:50pm.

  3. Foundation Update - August 2016

    ... upcoming webinars: •  Understanding the Complement System and the PNH Clone ; August 11, 2016 1:00 PM EDT • Bone ...

    Article last updated 10/09/2017 - 2:52pm.

  4. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Page last updated 09/30/2017 - 11:34am.

  5. Special Precautions

    ... risky for people with PNH because it: Makes the complement system more active, which can cause hemolysis Increases the ...

    Topic section last updated 09/08/2017 - 12:34pm.

  6. Youmna Kfoury, PhD

    ... libraries, we used the Clontech SMARTer Ultra low input RNA system which were then sequenced on Illumina Hiseq2000 instrument, resulting in ... the co-culture. In the case of up regulated genes we will complement our CRISPR based knock out with an over expression strategy. ...

    Grant Recipient last updated 12/15/2016 - 12:56pm.

  7. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... diseases of excess activation of the alternative pathway of complement that are treated with eculizumab , a humanized monoclonal ... dysregulation and validating the modified Ham test as a system for preclinical drug development for atypical hemolytic uremic syndrome. ...

    Research Article last updated 11/28/2016 - 11:42am.

  8. Local TV covers AAMDSIF Peer Support Networker

    ...   PNH is an acquired rare disorder characterized the complement system destructing red blood cells to early. Red blood cells are missing ...

    Article last updated 11/28/2016 - 3:21pm.

  9. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... proteins involved in the regulation of the complement system renders PNH erythrocytes susceptible to complement-mediated lysis. Clinical manifestations include thromboembolic ...

    Research Article last updated 09/13/2016 - 1:53pm.

  10. Interviews with the Experts: The Complement System in PNH

    ... association it has with PNH, what is the function of the complement system ? The complement system initially got that name because it ...

    Interview last updated 08/31/2016 - 8:39am.