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  1. STAT3-mutations indicate the presence of subclinical T cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.

    ... of HLADR15 were found. MDSs harboring a STAT3 mutant clone showed lower degree of BM cellularity and a higher frequency ...

    Research Article last updated 07/29/2014 - 11:59am.

  2. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... Complete responders had a decrease in red cell clone size while good partial responders had an increase. Thirteen patients ... failure, underlying inflammatory conditions and red cell clone size following treatment. Normalization of hemoglobin with decrease in ...

    Research Article last updated 11/05/2012 - 10:28am.

  3. Nurse's Corner Summer 2015: Understanding the Etiology and Epidemiology of Myelodysplastic Syndromes

    ... is complex including interplay between a neoplastic clone and an inflammatory environment that early in the disease leads to ...

    Page last updated 07/27/2015 - 12:04pm.

  4. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 05/14/2015 - 1:53pm.

  5. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 04/15/2015 - 9:39am.

  6. Eltrombopag now an approved therapy for certain patients with severe aplastic anemia

    ... we excluded patients with active PNH, and/or with PNH clone size greater than 50 percent” said Dunbar.  “We were treating ... PNH clones smaller than 50 percent were treated, and their clone sizes tended to remain approximately the same.” Read more on our ...

    Page last updated 08/27/2014 - 2:19pm.

  7. North American Pediatric Aplastic Anemia Consortium Symposium

    ... precursors. However, in the absence of an MDS defining clone , such as monosomy 7 , these overlapping morphologies can make ...

    Page last updated 10/31/2013 - 4:06pm.

  8. Ramon V. Tiu, MD

    ... aplastic anemia. None of the patients had a PNH clone at presentation. Improvements in blood counts were noted in three out ... cyclosporine . All four patients have not developed a PNH clone. In December 2011, Astellas Pharma US announced that the company has ...

    Grant Recipient last updated 10/30/2012 - 6:28pm.

  9. Research Overview - Recent Past Progress and Projections for the Near-Term

    ... where it worked exceptionally well to suppress the clone . It was not until after its FDA approval, that we went back to the ... in deletion 5q that allowed lenalidomide to suppress the clone. Later, as patients failed lenalidomide, we went back and studied the ...

    Interview last updated 02/10/2014 - 9:40am.

  10. Research Overview – Recent Past Progress and Projections for the Near-Term

    ... where it worked exceptionally well to suppress the clone and that this was a different mechanism altogether. We went back to ... targets in deletion 5q  allowed lenalimide to suppress the clone. Then when patients failed lenalidomide , we went back and studied ...

    Page last updated 01/14/2014 - 11:47am.