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  1. Shahram Kordasti, MD, PhD

    ... recruited 16 AA patients with a small to moderate PNH clone (with no cases of hemolytic PNH) and 8 age matched healthy volunteers ...

    Grant Recipient last updated 08/02/2016 - 3:35pm.

  2. Phase 1 Study of TCP-ATRA for Adult Patients With AML and MDS (TCP-ATRA)

    ... (ATRA), which effectively differentiates the leukemic clone . Over 80% of APL patients can be cured with ATRA based therapies. For ...

    Clinical Trial last updated 04/29/2016 - 12:33pm.

  3. Prognostic value of telomere attrition in patients with aplastic anemia

    ... of a paroxysmal nocturnal hemoglobinuria (PNH) clone and reticulocyte count. Telomere length ...

    Research Review last updated 05/02/2016 - 9:25am.

  4. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... known PNH ( paroxysmal nocturnal hemoglobinuria ) clone         No concurrent hormonal oral contraceptive use   ... PNH ( paroxysmal nocturnal hemoglobinuria ) clone where tested   Intervention:  ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  5. Gene Mutations in Aplastic Anemia

    ... often formed abnormal clones gradually. The pace of clone development had no effect on blood counts or development of abnormal ...

    Research Review last updated 05/02/2016 - 9:15am.

  6. Insights into the Natural History of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis of the Presenting Clinical, Haematological and Flow Cytometric Features of 705 Patients Leads to Improved Classification and Prediction of Clinical Course

    ... thrombosis (clots in blood vessels), and PNH clone size could be a powerful predictor of disease course. ...

    Research Review last updated 05/02/2016 - 9:20am.

  7. Dr. Vivienne Rebel reviews a recent study about p53 protein levels as a prognostic factor in MDS

    ... technology for identifying patients with a small clone of p53 mutated cells.  A disadvantage of IH is that it will not ...

    Research Review last updated 05/02/2016 - 9:17am.

  8. Clinical mutations associated with MDS and their importance for disease outcome

    ... mutated gene was found in all cells or only in a subset ( clone ); this stresses the importance of early detection of these gene ...

    Research Review last updated 05/02/2016 - 9:21am.

  9. PNH - Basics

    ... PNH red blood cells. Doctors also call them your PNH clone . The PNH red blood cells lack the shield of proteins that protect ...

    Topic section last updated 04/05/2016 - 4:02pm.

  10. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 05/14/2015 - 1:53pm.