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  1. Clone of Financials

    Annual Reports Form 990 Financial Audits 2014 Annual Report 2014 Form 990 2014 Financial Audit 2013 Annual Repor...

    Page last updated 03/31/2016 - 5:46pm.

  2. Clone of Research Investment

    The Foundation supports scientific/medical research projects with two-year grants of $30,000 per year for new and established investigators to test fresh theories and explore existing research leads in aplastic...

    Page last updated 03/31/2016 - 5:43pm.

  3. Clone of Aplastic Anemia

    The Basics Aplastic anemia can be moderate, severe or very severe. People with severe or very severe aplastic anemia are at risk for life-thre...

    Page last updated 03/13/2016 - 12:46pm.

  4. David Araten, MD

    ... in PNH includes the  expansion of an abnormal stem cell clone in the bone marrow (called clonal expansion) which can by itself ... a very large percentage of the patient's blood cells. This clone has as its feature the presence of a mutation in a gene called ...

    Grant Recipient last updated 11/30/2016 - 10:51am.

  5. Chao-Yie Yang, MD, PhD

    ... which is expensive, unable to eradicate PNH clone , not orally available, requires clinic-bound infusions via iv access ... which is expensive, unable to eradicate PNH clone , not oral available and requires lifelong administration in clinics. ...

    Grant Recipient last updated 08/09/2016 - 1:02pm.

  6. MDS and Inflammation

    ... and are genetically distinct or separate from the MDS clone . This findings suggests that MDSCs –may have preceded, and drive the emergence of the MDS clone. We have also learned that MDSC’s are expanded and activated by a ...

    Interview last updated 02/14/2017 - 8:52am.

  7. Anastasios Karadimitris, MD, PhD

    ... with up to 50% of patients with IAA developing a PNH clone or bonafide PNH and a subgroup of patients with PNH evolving into ...

    Grant Recipient last updated 03/07/2017 - 9:50am.

  8. New therapeutics for myelodysplastic syndromes

    ... intrinsic to the defective stem cell itself (the “MDS clone”), as well as to imbalances among the surrounding, non-cancerous cells ...  In this model, progression of an autonomous MDS clone is marked by an increasing independence from its surrounding ...

    Research Review last updated 05/02/2016 - 9:28am.

  9. Interviews with the Experts: The Complement System in PNH

    ... Subclinical PNH implies that you have a PNH clone [state that PNH is defective red blood cell??] that isn’t ... is identified, it is important to monitor the sized of the clone and understand the potential consequences of clone growth and the potential for hemolytic events to begin. ...

    Interview last updated 08/31/2016 - 8:39am.

  10. 2015 PNH Research Grant Guidelines

    ... stem cells Cause of the expansion of the PNH clone to clinically significant levels Genetic components of PNH ...

    Page last updated 08/25/2016 - 12:55pm.