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  1. PNH - Basics

    ... PNH red blood cells. Doctors also call them your PNH clone . The PNH red blood cells lack the shield of proteins that protect ...

    Topic section last updated 04/05/2016 - 4:02pm.

  2. Multiparameter FLAER-based flow cytometry for screening of paroxysmal nocturnal hemoglobinuria enhances detection rates in patients with aplastic anemia

    ... detection of paroxysmal nocturnal hemoglobinuria (PNH) clone . This study aimed to compare PNH clone detection by flow cytometry in the pre-FLAER era versus the FLAER era. ...

    Research Article last updated 01/20/2015 - 2:45pm.

  3. Performance characteristics of consensus approaches for small and minor paroxysmal nocturnal hemoglobinuria clone determination by flow cytometry.

    Journal Title:  Clin Chem Lab Med Primary Author:  Marinov I Author(s):  Mari...

    Research Article last updated 07/09/2013 - 3:33pm.

  4. A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data

    ... and CD15 in granulocytes to 0.1%. Twenty-four PNH minor clone -positive samples (minor-PNH+) were taken, in which the clone population was <5% of RBCs and/or granulocytes. Excluding PNH and ...

    Research Article last updated 03/02/2015 - 11:39am.

  5. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... of the HLA alleles, linking immune escape to clone emergence. Two patients had activating mutations in key signaling ...

    Research Article last updated 04/07/2015 - 1:05pm.

  6. Daria Babushok, MD, PhD

    ... blood cells originate from the same early cell forming a “clone” is known as “clonal hematopoiesis”, and, in aplastic anemia, it is ...

    Bio last updated 03/11/2016 - 1:41pm.

  7. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... were replaced by new clones, in 17.3% the same clone was present before HCT and at relapse, and in 9.7%, no abnormalities ...

    Research Article last updated 06/03/2015 - 12:48pm.

  8. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... proteins is hypothesized to provide the mutant clone with an extrinsic growth advantage, but some features of PNH argue ... stepwise clonal evolution derived from a singular stem cell clone. Bone Marrow Diseases:  ...

    Research Article last updated 10/02/2014 - 8:24am.

  9. Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes

    ... marrow failure, and assayed for the presence of a PNH clone in the pediatric or adult hematology/oncology clinics from 2001 to ... are needed, our results suggest that the detection of a PNH clone can be a useful diagnostic tool to exclude the diagnosis of IBMFS and ...

    Research Article last updated 04/09/2014 - 9:04am.

  10. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... or detectable paroxysmal nocturnal hemoglobinuria clone , irrespective of treatment. In addition to evaluating the long-term ... granulocyte paroxysmal nocturnal hemoglobinuria clone size was 68.1% (range, 0.01%-100%). Overall, 16% of patients had a ...

    Research Article last updated 03/06/2014 - 11:30am.