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  1. Daria Babushok, MD, PhD

    ... blood cells originate from the same early cell forming a “clone” is known as “clonal hematopoiesis”, and, in aplastic anemia, it is ...

    Bio last updated 03/11/2016 - 1:41pm.

  2. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... disease natural history by suppressing the malignant clone . Data discussed here from the pivotal phase 2 (MDS-003) and phase 3 ...

    Research Article last updated 12/08/2015 - 1:06pm.

  3. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... were replaced by new clones, in 17.3% the same clone was present before HCT and at relapse, and in 9.7%, no abnormalities ...

    Research Article last updated 06/03/2015 - 12:48pm.

  4. Nurse's Corner Summer 2015: Understanding the Etiology and Epidemiology of Myelodysplastic Syndromes

    ... is complex including interplay between a neoplastic clone and an inflammatory environment that early in the disease leads to ...

    Page last updated 07/27/2015 - 12:04pm.

  5. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... of the HLA alleles, linking immune escape to clone emergence. Two patients had activating mutations in key signaling ...

    Research Article last updated 04/07/2015 - 1:05pm.

  6. A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data

    ... and CD15 in granulocytes to 0.1%. Twenty-four PNH minor clone -positive samples (minor-PNH+) were taken, in which the clone population was <5% of RBCs and/or granulocytes. Excluding PNH and ...

    Research Article last updated 03/02/2015 - 11:39am.

  7. Multiparameter FLAER-based flow cytometry for screening of paroxysmal nocturnal hemoglobinuria enhances detection rates in patients with aplastic anemia

    ... detection of paroxysmal nocturnal hemoglobinuria (PNH) clone . This study aimed to compare PNH clone detection by flow cytometry in the pre-FLAER era versus the FLAER era. ...

    Research Article last updated 01/20/2015 - 2:45pm.

  8. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 05/14/2015 - 1:53pm.

  9. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 04/15/2015 - 9:39am.

  10. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... proteins is hypothesized to provide the mutant clone with an extrinsic growth advantage, but some features of PNH argue ... stepwise clonal evolution derived from a singular stem cell clone. Bone Marrow Diseases:  ...

    Research Article last updated 10/02/2014 - 8:24am.