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1. Clone of Aplastic Anemia

   The Basics Aplastic anemia can be moderate, severe or very severe. People with severe or very severe aplastic anemia are at risk for life-thre...

   Page last updated 03/13/2016 - 12:46pm.

2. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

   ... disease natural history by suppressing the malignant clone . Data discussed here from the pivotal phase 2 (MDS-003) and phase 3 ...

   Research Article last updated 12/08/2015 - 1:06pm.

3. Prognostic value of telomere attrition in patients with aplastic anemia

   ... of a paroxysmal nocturnal hemoglobinuria (PNH) clone and reticulocyte count. Telomere length ...

   Research Review last updated 05/02/2016 - 9:25am.

4. Phase 1 Study of TCP-ATRA for Adult Patients With AML and MDS (TCP-ATRA)

   ... (ATRA), which effectively differentiates the leukemic clone . Over 80% of APL patients can be cured with ATRA based therapies. For ...

   Clinical Trial last updated 04/29/2016 - 12:33pm.

5. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

   ... known PNH ( paroxysmal nocturnal hemoglobinuria ) clone         No concurrent hormonal oral contraceptive use   ... PNH ( paroxysmal nocturnal hemoglobinuria ) clone where tested   ...

   Clinical Trial last updated 05/02/2016 - 2:31pm.

6. Gene Mutations in Aplastic Anemia

   ... often formed abnormal clones gradually. The pace of clone development had no effect on blood counts or development of abnormal ...

   Research Review last updated 05/02/2016 - 9:15am.

7. Insights into the Natural History of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis of the Presenting Clinical, Haematological and Flow Cytometric Features of 705 Patients Leads to Improved Classification and Prediction of Clinical Course

   ... thrombosis (clots in blood vessels), and PNH clone size could be a powerful predictor of disease course. ...

   Research Review last updated 05/02/2016 - 9:20am.

8. Dr. Vivienne Rebel reviews a recent study about p53 protein levels as a prognostic factor in MDS

   ... technology for identifying patients with a small clone of p53 mutated cells.  A disadvantage of IH is that it will not ...

   Research Review last updated 05/02/2016 - 9:17am.

9. Clinical mutations associated with MDS and their importance for disease outcome

   ... mutated gene was found in all cells or only in a subset ( clone ); this stresses the importance of early detection of these gene ...

   Research Review last updated 05/02/2016 - 9:21am.

10. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... PNH ( paroxysmal nocturnal hemoglobinuria ) clone where tested Concurrent hormonal contraceptive use ...

    Clinical Trial last updated 04/29/2016 - 9:59am.