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  1. Hypomethylating agents in myelodysplastic syndromes changing the inevitable: the value of azacitidine as maintenance therapy, effects on transfusion and combination with other agents.

    ... has a progressively cumulative effect on the MDS clone and support the value of maintenance therapy. Prolonged survival was ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia

    ... of a paroxysmal nocturnal hemoglobinuria clone (P=0.01) and a pretreatment absolute reticulocyte count ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... a glycosylphosphatidylinositol-anchor protein-deficient clone was detected in 83 (40%) patients pre-treatment, and the median clone size was 9.7% (interquartile range 3.5-29). In patients without a ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... of the HLA alleles, linking immune escape to clone emergence. Two patients had activating mutations in key signaling ...

    Research Article last updated 04/07/2015 - 1:05pm.

  5. Loss of expression of neutrophil proteinase-3: a contributory factor in thrombotic risk in paroxysmal nocturnal hemoglobinuria.

    ... with a decrease in plasma proteinase 3 levels, clone size and history of thrombosis . In addition, we found that ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.

    ... Twenty-seven patients with AA and a detectable PNH clone were monitored for a median of 5.7 years (range1.5 to 11.5 years). ... The erythrocyte and granulocyte PNH clone sizes were measured using flow cytometry and analyzed via CellQuest ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Understanding the Compliment System and the PNH Clone

    ... role of the complement system in relation to PNH clone . He will describe for you, in simple terms, how the complement system ... Understanding the Compliment System and the PNH Clone ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  8. Alina Dulau Florea, MD

    ... that were pre-determined. Our data show that the PNH clone size measured in BM mature neutrophils, monocytes and immature ... red cells correlates well with that in PB neutrophils.  The clone size among mature lymphocytes is smaller than in other white cells, most ...

    Grant Recipient last updated 01/12/2018 - 9:50am.

  9. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... Complete responders had a decrease in red cell clone size while good partial responders had an increase. Thirteen patients ... failure, underlying inflammatory conditions and red cell clone size following treatment. Normalization of hemoglobin with decrease in ...

    Research Article last updated 11/05/2012 - 10:28am.

  10. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... were replaced by new clones, in 17.3% the same clone was present before HCT and at relapse, and in 9.7%, no abnormalities ...

    Research Article last updated 06/03/2015 - 12:48pm.