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  1. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... the probability of developing a cytogenetically abnormal clone . A significantly increased number of telomere signal-free chromosomal ... of an autonomous and clinically detectable abnormal clone. Marrow cells of clinically healthy individuals carrying loss-of-function ...

    Research Article last updated 10/31/2011 - 2:58pm.

  2. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... of the HLA alleles, linking immune escape to clone emergence. Two patients had activating mutations in key signaling ...

    Research Article last updated 04/07/2015 - 1:05pm.

  3. Expression of DLK1 Gene in the Bone Marrow Cells of Patients with Myelodysplastic Syndromes and Its Clinical Significance.

    ... DLK1 (≥0.8) presented significantly higher malignant clone burden (0.4134±0.3999) than those with lower DLK1 expression ... A high expression of DLK1 gene suggested a higher malignant clone burden of MDS. Bone Marrow Diseases:  ...

    Research Article last updated 06/20/2013 - 10:42am.

  4. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... agent that selectively suppresses the del(5q) clone . While the mechanism is not fully understood, it is associated with ...

    Research Article last updated 04/17/2014 - 11:29am.

  5. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... proteins, making red blood cells (RBC) derived from the clone more sensitive to complement mediated hemolysis . The ...

    Research Article last updated 10/22/2013 - 3:44pm.

  6. Epigenetic alterations and microRNAs: New players in the pathogenesis of myelodysplastic syndromes.

    ... too. Myelodysplastic syndromes (MDS) are clone disorders of the hematopoietic stem cell with increased risk of ...

    Research Article last updated 06/28/2013 - 1:36pm.

  7. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH granulocytes) is approximately 16 per million, and ...

    Research Article last updated 05/14/2013 - 3:28pm.

  8. Immunomodulating drugs in myelodysplastic syndromes

    ... is probably a direct cytotoxic activity on the del5q clone . This possibly specific effect is currently being investigated in ...

    Research Article last updated 01/09/2012 - 2:00pm.

  9. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... (PNH) is a rare acquired disease characterized by a clone of blood cells lacking glycosyl inostitol phosphatidyl (GPI) anchored ...

    Research Article last updated 11/21/2011 - 3:08pm.

  10. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and ...

    Research Article last updated 10/11/2011 - 5:58pm.