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  1. Clonal hematopoiesis in acquired aplastic anemia

    ... and PIGA mutations tend to disappear or show stable clone size and predict significantly better response to IST and clinical ... ASXL1, and other genes, which are likely to increase their clone size and associated with a faster progression to MDS/AML and predict an ...

    Research Article last updated 06/22/2016 - 10:18am.

  2. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... anemia . PNH results from expansion of a clone of hematopoietic cells that, as a consequence of an inactivating ... proteins CD55 and CD59, the red cells arising from this clone are exquisitely sensitive to lysis by activated complement. Until a ...

    Research Article last updated 06/07/2016 - 10:56am.

  3. Interviews with the Experts: The Complement System in PNH

    ... Subclinical PNH implies that you have a PNH clone [state that PNH is defective red blood cell??] that isn’t ... is identified, it is important to monitor the sized of the clone and understand the potential consequences of clone growth and the potential for hemolytic events to begin. ...

    Interview last updated 08/31/2016 - 8:39am.

  4. Chao-Yie Yang, MD, PhD

    ... which is expensive, unable to eradicate PNH clone , not orally available, requires clinic-bound infusions via iv access ... which is expensive, unable to eradicate PNH clone , not oral available and requires lifelong administration in clinics. ...

    Grant Recipient last updated 08/09/2016 - 1:02pm.

  5. 2015 PNH Research Grant Guidelines

    ... stem cells Cause of the expansion of the PNH clone to clinically significant levels Genetic components of PNH ...

    Page last updated 08/25/2016 - 12:55pm.

  6. Understanding the Compliment System and the PNH Clone

    ... role of the complement system in relation to PNH clone . He will describe for you, in simple terms, how the complement system ... Understanding the Compliment System and the PNH Clone ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  7. Clone of Clone of Caring for Yourself

    Another side to effective patient behavior The key to becoming an empowered patient is simply deciding to make your life the best it can be. People with bone marrow failure and other chronic diseas...

    Page last updated 04/11/2016 - 12:34pm.

  8. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

    ... recurrent somatic mutations identified in the diseased clone on response to lenalidomide and the drug effects on clonal evolution ...

    Research Article last updated 04/29/2016 - 11:33am.

  9. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... than those transplanted with fewer blasts, the effect of clone size in patients with MDS without increased blast proportion is ...

    Research Article last updated 04/29/2016 - 10:22am.

  10. Shahram Kordasti, MD, PhD

    ... recruited 16 AA patients with a small to moderate PNH clone (with no cases of hemolytic PNH) and 8 age matched healthy volunteers ...

    Grant Recipient last updated 08/02/2016 - 3:35pm.