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  1. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... than those transplanted with fewer blasts, the effect of clone size in patients with MDS without increased blast proportion is ...

    Research Article last updated 04/29/2016 - 10:22am.

  2. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... disease natural history by suppressing the malignant clone . Data discussed here from the pivotal phase 2 (MDS-003) and phase 3 ...

    Research Article last updated 12/08/2015 - 1:06pm.

  3. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

    ... (MDS) are clonally heterogeneous, with a founding clone and multiple subclones. It is not known whether specific gene ... the range of variant allele frequencies (VAFs) for founding clone mutations. At least one mutation or cytogenetic abnormality was ...

    Research Article last updated 03/05/2013 - 8:30am.

  4. A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data

    ... and CD15 in granulocytes to 0.1%. Twenty-four PNH minor clone -positive samples (minor-PNH+) were taken, in which the clone population was <5% of RBCs and/or granulocytes. Excluding PNH and ...

    Research Article last updated 03/02/2015 - 11:39am.

  5. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... proteins is hypothesized to provide the mutant clone with an extrinsic growth advantage, but some features of PNH argue ... stepwise clonal evolution derived from a singular stem cell clone. Bone Marrow Diseases:  ...

    Research Article last updated 10/02/2014 - 8:24am.

  6. Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes

    ... marrow failure, and assayed for the presence of a PNH clone in the pediatric or adult hematology/oncology clinics from 2001 to ... are needed, our results suggest that the detection of a PNH clone can be a useful diagnostic tool to exclude the diagnosis of IBMFS and ...

    Research Article last updated 04/09/2014 - 9:04am.

  7. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... or detectable paroxysmal nocturnal hemoglobinuria clone , irrespective of treatment. In addition to evaluating the long-term ... granulocyte paroxysmal nocturnal hemoglobinuria clone size was 68.1% (range, 0.01%-100%). Overall, 16% of patients had a ...

    Research Article last updated 03/06/2014 - 11:30am.

  8. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis. METHODS: Patients, selected from medical ... (7.8%). Among patients with PNH clones ≥ 1%, median clone size was smaller in patients with AA (5.1%) than in those with MDS ...

    Research Article last updated 11/21/2013 - 11:54am.

  9. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis. Methods: Patients, selected from medical office ... (7.8%). Among patients with PNH clones ≥ 1%, median clone size was smaller in patients with AA (5.1%) than in those with MDS ...

    Research Article last updated 10/22/2013 - 3:42pm.

  10. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... the probability of developing a cytogenetically abnormal clone . A significantly increased number of telomere signal-free chromosomal ... of an autonomous and clinically detectable abnormal clone. Marrow cells of clinically healthy individuals carrying loss-of-function ...

    Research Article last updated 10/31/2011 - 2:58pm.