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  1. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis. Methods: Patients, selected from medical office ... (7.8%). Among patients with PNH clones ≥ 1%, median clone size was smaller in patients with AA (5.1%) than in those with MDS ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... proteins is hypothesized to provide the mutant clone with an extrinsic growth advantage, but some features of PNH argue ... stepwise clonal evolution derived from a singular stem cell clone. Bone Marrow Diseases:  ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Expression of DLK1 Gene in the Bone Marrow Cells of Patients with Myelodysplastic Syndromes and Its Clinical Significance.

    ... DLK1 (≥0.8) presented significantly higher malignant clone burden (0.4134±0.3999) than those with lower DLK1 expression ... A high expression of DLK1 gene suggested a higher malignant clone burden of MDS. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... disease natural history by suppressing the malignant clone . Data discussed here from the pivotal phase 2 (MDS-003) and phase 3 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... agent that selectively suppresses the del(5q) clone . While the mechanism is not fully understood, it is associated with ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... proteins, making red blood cells (RBC) derived from the clone more sensitive to complement mediated hemolysis . The ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Epigenetic alterations and microRNAs: New players in the pathogenesis of myelodysplastic syndromes.

    ... too. Myelodysplastic syndromes (MDS) are clone disorders of the hematopoietic stem cell with increased risk of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH granulocytes) is approximately 16 per million, and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Immunomodulating drugs in myelodysplastic syndromes

    ... is probably a direct cytotoxic activity on the del5q clone . This possibly specific effect is currently being investigated in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... (PNH) is a rare acquired disease characterized by a clone of blood cells lacking glycosyl inostitol phosphatidyl (GPI) anchored ...

    Research Article last updated 07/20/2018 - 5:14pm.