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  1. A phase 2 trial of high dose lenalidomide in patients with relapsed/refractory higher-risk myelodysplastic syndromes and acute myeloid leukaemia with trilineage dysplasia

    ... but there is limited data in the RR setting. This phase II trial included patients with RR HR-MDS or AML-TD at 2 doses of lenalidomide (15 ... ≥1 year. The study was terminated due to lack of robust clinical activity. In conclusion, lenalidomide at 15 mg is ineffective in RR ...

    Research Article last updated 11/02/2016 - 9:17am.

  2. Top expert calls future MDS/AML care “promising”

    ... on] where the research is going, what are the most important clinical trials that we have for our patients, and some other interventions ... The traditional dogma of a big survival-based randomized trial is not possible for some of these particular groups of patients. ...

    Article last updated 11/02/2016 - 11:28am.

  3. REVERSE 1 INCB 18424-271

    For more details on this clinical trial, including contact information, please see this trial’s listing on ... the efficacy, appropriateness or suitability of any clinical trial listed on this website. Pharmaceutical company sponsored ...

    Clinical Trial last updated 12/14/2016 - 11:24am.

  4. Comparative clinical effectiveness of azacitidine versus decitabine in older patients with myelodysplastic syndromes

    ... randomized trials. The two drugs have not been compared in clinical trials. We identified patients diagnosed with MDS between 2004 and ... was substantially shorter than in the AZA-001 clinical trial (11 versus 24·5 months). ...

    Research Article last updated 10/06/2016 - 11:34am.

  5. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    For more details on this clinical trial, including contact information, please see this trial’s listing on ... the study: a.         Previous participation in a clinical study of IV or oral rigosertib; however, patients who failed screening ...

    Clinical Trial last updated 11/29/2016 - 8:29am.

  6. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... data from Europe, and from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN), a non-randomized prospective study in ... treatment for refractory aplastic anemia. Results of the NIH trial of upfront treatment with eltrombopag plus IST are eagerly awaited. What ...

    Interview last updated 11/28/2016 - 2:58pm.

  7. Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study.

    ... in older patients who are often treated outside the clinical trial setting. Consequently, our understanding of the patterns of ...

    Research Article last updated 09/19/2016 - 11:05am.

  8. San Diego Family Takes Action for Awareness

    ... have – and he was put on azacitidine. We also learned a clinical study of oral azacitidine – taken by mouth, in pill form. We were ... biopsy to see if prospective patients are qualified for the trial. However, because he remained in high-risk status he wasn’t qualified, ...

    Patient Chronicle last updated 10/26/2016 - 11:42am.

  9. Taming the nausea, vomiting caused by chemo

    ... , according to results from a large NCI-funded phase III clinical trial . Patients in the trial were being treated with chemotherapy ...

    Article last updated 08/11/2016 - 3:27pm.

  10. Interviews with the Experts: Dr. Bart Scott on PNH

    ... does. Because it is so rare, it’s hard to design a clinical trial to study the disease in a comprehensive manner. So few have it, and ...

    Interview last updated 09/23/2016 - 2:33pm.