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  1. Comparative clinical effectiveness of azacitidine versus decitabine in older patients with myelodysplastic syndromes

    ... randomized trials. The two drugs have not been compared in clinical trials. We identified patients diagnosed with MDS between 2004 and ... was substantially shorter than in the AZA-001 clinical trial (11 versus 24·5 months). ...

    Research Article last updated 10/06/2016 - 11:34am.

  2. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... cells that underwent ex-vivo T cell depletion. This trial started in 2009 and was the first of its kind for aplastic anemia. It’s ... Position / Title:  Clinical Director Institution:  ...

    Interview last updated 10/04/2017 - 1:36pm.

  3. Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study.

    ... in older patients who are often treated outside the clinical trial setting. Consequently, our understanding of the patterns of ...

    Research Article last updated 09/19/2016 - 11:05am.

  4. Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best supportive care in patients with IPSS lower-risk myelodysplastic syndromes and po

    ... modifier azacitidine . In an expanded phase 1 trial, CC-486 demonstrated clinical and biological activity in patients with International Prognostic ...

    Research Article last updated 06/23/2016 - 10:17am.

  5. Taming the nausea, vomiting caused by chemo

    ... , according to results from a large NCI-funded phase III clinical trial . Patients in the trial were being treated with chemotherapy ...

    Article last updated 08/11/2016 - 3:27pm.

  6. Top expert calls future MDS/AML care “promising”

    ... on] where the research is going, what are the most important clinical trials that we have for our patients, and some other interventions ... The traditional dogma of a big survival-based randomized trial is not possible for some of these particular groups of patients. ...

    Article last updated 11/02/2016 - 11:28am.

  7. Major news in BMT with half-match donors

    ... and the primary investigator of many UT Southwestern clinical trials related to bone marrow transplantation. Mr. Dandridge enrolled in one such UT Southwestern clinical trial , studying a therapy called AG-221, developed by Agios Pharmaceuticals ...

    Article last updated 06/14/2016 - 3:02pm.

  8. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

    ... MDS patients randomized in the GFM-Len-Epo2008 clinical trial to lenalidomide or lenalidomide + EPO. Clonal evolution was analyzed ...

    Research Article last updated 04/29/2016 - 11:33am.

  9. Personalized medicine for MDS

    ... in myelodysplastic syndromes: wishful thinking or already clinical reality? Original ... approach, however, has not been tested in a clinical trial .  -One personalized approach for lower-risk patients with MDS ...

    Research Review last updated 05/02/2016 - 9:44am.

  10. Self-injected PNH therapy on the horizon

    ... positive interim data from the first cohort in its phase Ib trial that show maintenance of complement inhibition using Coversin in healthy ... diseases, and Alexion presented the first clinical data for its own next-generation complement inhibitors. Overall, we ...

    Article last updated 07/07/2016 - 9:40am.