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  1. Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System.

    ... cytogenetics, 4.8 for complex abnormalities harboring chromosomes 5 and/or 7, and 3.1 for a blast count of 21% to 30% (P < .01 ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Coleman Lindsley, MD, PhD

    ... leukemia. Telomeres are caps that protects the ends of chromosomes from deterioration, and are important for preventing premature ...

    Grant Recipient last updated 06/05/2017 - 11:04am.

  3. Prediction of outcomes after allogeneic stem cell transplantation for myelodysplastic syndromes

    ... normally, every human cell contains 22 pairs of non-sex chromosomes and one pair of sex chromosomes (the X and Y chromosomes) but in a monosomal karyotype there are at ...

    Research Review last updated 05/02/2016 - 9:29am.

  4. Interviews with the Experts MDS Genomics: Providing ‘Street View’ Directions of Disease

    ... “Genomics” is the umbrella term for any study of chromosomes , genes, and DNA in a cell. “Genetics” is a more specific ... fit when talking about MDS because MDS doctors look at whole chromosomes and specifi c genes when trying to understand each patient’s ...

    Interview last updated 09/23/2014 - 9:30am.

  5. Specialized technique effective in identifying chromosomal abnormalities, improving prognosis for MDS

    ... cytogenetics (branch of genetics which studies the chromosomes ), and the number of cytopenias (reduction in the number of ... cytogenetics. Metaphase cytogenetics means studying chromosomes in the middle of the cell cycle (during a specific time when the ...

    Research Review last updated 05/02/2016 - 9:31am.

  6. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... involve telomere diseases (the ends of our chromosomes that protect our DNA). The mutations that lead to these ...

    Interview last updated 02/14/2017 - 8:34am.

  7. Immune System Suppression and Bone Marrow Failure

    ... TERC genes, which help maintain telomeres (ends of chromosomes ), play an important role in aplastic anemia. Telomeres are ... of certain genes and changes in or losses of certain chromosomes inside bone marrow that is not working properly. The failed bone ...

    Research Review last updated 05/02/2016 - 9:15am.

  8. Prognostic value of telomere attrition in patients with aplastic anemia

    ... (special molecules for building DNA) at the ends of chromosomes that are there to protect the chromosomes from damage and breakdown. As we age over time, telomeres shorten ...

    Research Review last updated 05/02/2016 - 9:25am.

  9. Luis Batista, PhD

    ... Telomeres represent the extremities of our chromosomes and are composed of long stretches of repetitive DNA sequences ...

    Grant Recipient last updated 06/09/2015 - 9:22am.

  10. MDS and MDS/MPN: Past, Present, and Future 2014 American Society of Hematology (ASH) Satellite Symposium Summary for Patients and Families

    ... Conventional cytogenetics is a method to analyze chromosomes . Researchers and clinicians use conventional cytogenetics to ... used alone, today’s advanced techniques to study genes and chromosomes don’t give enough information to find out what type of MDS ...

    Page last updated 03/13/2015 - 5:00pm.