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  1. StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies

    ... slow early response at Day 14, or Hypodiploidy (< 44 chromosomes or DNA index < 0.81), or End of induction M3 bone ...

    Clinical Trial last updated 06/03/2016 - 2:37pm.

  2. Genetics factors associated with myelodysplastic syndromes

    ... common alterations, and often involve the long arms of chromosomes 5, 7, 8, 13, and 20 and the short arms of chromosomes 12 and 17. The advent of new technologies for the detection of ...

    Research Article last updated 06/03/2015 - 11:30am.

  3. Reciprocal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemias: Review of 5,654 patients with an evaluable karyotype.

    ... Journal Title:  Genes Chromosomes Cancer Primary ... in 183 (86%) cases and unbalanced in 30 (14%) cases. All chromosomes were found to be involved in translocations, with the single ...

    Research Article last updated 07/29/2014 - 11:55am.

  4. MicroRNA-194-5p could serve as a diagnostic and prognostic biomarker in myelodysplastic syndromes

    ... was to investigate the involvement of miRNAs encoded by chromosomes 8 and 1q in MDS. For this, the expression of nine miRNAs ...

    Research Article last updated 06/03/2015 - 12:38pm.

  5. Dr. Vivienne Rebel reviews a recent study about p53 protein levels as a prognostic factor in MDS

    ... (i.e., the disappearance of cells with abnormal chromosomes , in this case cells that harbored a deletion of the long arm of ...

    Research Review last updated 05/02/2016 - 9:17am.

  6. Specific abnormalities versus number of abnormalities and cytogenetic scoring systems for outcome prediction after allogeneic hematopoietic SCT for myelodysplastic syndromes

    ... was adversely influenced by del 5q/-5, abnormalities of chromosomes 11 and 17 and cytogenetic IPSS-R very poor category. Karyotype with ⩽2 abnormalities and no abnormalities of chromosomes 3, 5, 7, 11 and 17 was an independent prognostic factor of lower ...

    Research Article last updated 05/22/2014 - 9:03am.

  7. Gene Mutations in Aplastic Anemia

    ... had no effect on blood counts or development of abnormal chromosomes , abnormal cells in the bone marrow, or leukemia. Patients ...

    Research Review last updated 05/02/2016 - 9:15am.

  8. Prognostic Relevance of the Kinetics of Worsening of Cytopenias in Lower-Risk MDS: A Substudy from the European Leukemianet Low Risk MDS (EUMDS) Registry

    ... on the IPSS or other MDS prognostic systems, or abnormal chromosomes . Conclusions: Faster drops in ANC and, to a lesser ...

    Research Review last updated 05/02/2016 - 9:27am.

  9. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... ends. As such, they prevent the natural ends of linear chromosomes from being subjected to DNA repair activities that would result ...

    Research Article last updated 08/07/2013 - 9:19am.

  10. Bone Marrow Transplant

    ... AML. Cytogenetics , or the study of abnormal chromosomes, can also affect SCT outcomes. People with secondary MDS , ... another disease or disorder, tend to have more abnormal chromosomes and worse outcomes after SCT than people with primary MDS. ...

    Topic section last updated 03/29/2016 - 7:27pm.