Search | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Reciprocal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemias: Review of 5,654 patients with an evaluable karyotype.

    Journal Title:  Genes Chromosomes Cancer Primary Author:  ... in 183 (86%) cases and unbalanced in 30 (14%) cases. All chromosomes were found to be involved in translocations, with the single ...

    Research Article last updated 07/29/2014 - 11:55am.

  2. Genetics factors associated with myelodysplastic syndromes

    ... common alterations, and often involve the long arms of chromosomes 5, 7, 8, 13, and 20 and the short arms of chromosomes 12 and 17. The advent of new technologies for the detection of ...

    Research Article last updated 06/03/2015 - 11:30am.

  3. Specific abnormalities versus number of abnormalities and cytogenetic scoring systems for outcome prediction after allogeneic hematopoietic SCT for myelodysplastic syndromes

    ... was adversely influenced by del 5q/-5, abnormalities of chromosomes 11 and 17 and cytogenetic IPSS-R very poor category. Karyotype with ⩽2 abnormalities and no abnormalities of chromosomes 3, 5, 7, 11 and 17 was an independent prognostic factor of lower ...

    Research Article last updated 05/22/2014 - 9:03am.

  4. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... ends. As such, they prevent the natural ends of linear chromosomes from being subjected to DNA repair activities that would result ...

    Research Article last updated 08/07/2013 - 9:19am.

  5. MicroRNA-194-5p could serve as a diagnostic and prognostic biomarker in myelodysplastic syndromes

    ... was to investigate the involvement of miRNAs encoded by chromosomes 8 and 1q in MDS. For this, the expression of nine miRNAs ...

    Research Article last updated 06/03/2015 - 12:38pm.

  6. Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene

    ... 11q23+/MLL- occurs rarely, involving different partner chromosomes and showing clinical and pathological features and disease ...

    Research Article last updated 09/19/2016 - 11:12am.

  7. Coleman Lindsley, MD, PhD

    ... leukemia. Telomeres are caps that protects the ends of chromosomes from deterioration, and are important for preventing premature ...

    Grant Recipient last updated 06/05/2017 - 11:04am.

  8. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... short telomeres. Telomeres are located at the ends of chromosomes and help keep chromosomes stable. As people age, their telomeres become shorter. Patients who ...

    Research Review last updated 05/02/2016 - 9:20am.

  9. Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System.

    ... cytogenetics, 4.8 for complex abnormalities harboring chromosomes 5 and/or 7, and 3.1 for a blast count of 21% to 30% (P < .01 ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... involve telomere diseases (the ends of our chromosomes that protect our DNA). The mutations that lead to these ...

    Interview last updated 02/14/2017 - 8:34am.