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  1. A Study To Evaluate PF-04449913 With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

    For more details on this clinical trial, including contact information, please see this trial’s listing on clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/NCT01546038 ...

    Clinical Trial last updated 04/27/2016 - 9:27am.

  2. Update on the pharmacotherapy for myelodysplastic syndromes

    ... relied upon supportive care and intensive chemotherapy . The last decade has seen many scientific and therapeutic ...

    Research Article last updated 08/21/2014 - 9:23am.

  3. Myelodysplastic syndromes

    ... in a third of patients. 15% of cases occur after chemotherapy or radiotherapy for a previous cancer; the syndromes are most ...

    Research Article last updated 04/16/2014 - 12:04pm.

  4. Microtransplantation to Treat Refractory or Relapsed Hematologic Malignancies in Younger Patients

    ... transplant, patients receive very high doses of chemotherapy and/or radiation therapy, followed by an infusion of their ... bone marrow or blood stem cells . The high-dose chemotherapy drugs and radiation are given to remove the leukemia cells in the ...

    Clinical Trial last updated 05/09/2016 - 3:01pm.

  5. Clinical results with the DNA hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in patients with myelodysplastic syndromes: an update

    ... Due to their lower toxicity compared to conventional chemotherapy , hypomethylating agents are often a safe and feasible ... may play a role in epigenetic "priming" before conventional chemotherapy. This review summarizes the results of clinical trials and ...

    Research Article last updated 11/05/2012 - 9:34am.

  6. Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System.

    ... care without specific therapy, with AML-like chemotherapy , or with other therapy regimens (low-dose chemotherapy, demethylating agents, immune modulating agents, valproic acid, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Selinexor (KPT-330) in Older Patients With Relapsed/Refractory AML (SOPRA)

    ... AML who are ineligible for standard intensive chemotherapy and/or transplantation. In the Selinexor in Older Patient with ... and are currently deemed unfit for intensive chemotherapy . ECOG ≤ 2. Must have available archival or recently ...

    Clinical Trial last updated 08/26/2016 - 9:21am.

  8. Transplantation strategies for the management of patients with myelodysplastic syndromes.

    ... are almost equal with the results obtained by intensive chemotherapy alone. Failure was due primarily to TRM in patients with ... the procedure. Autologous SCT after successful induction chemotherapy may increase the proportion of long-term survivors, thus ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. GVHD Prophylaxis With Post Transplant Cyclophosphamide for Patients With Renal Insufficiency Undergoing a Conventional 8/8 HLA-matched Related or Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplant

    ... is to test the safety and benefit of giving a type of chemotherapy - cyclophosphamide - after the transplant to prevent ... induction and at least one course of consolidation chemotherapy pretransplant Patients must have a Karnofsky ...

    Clinical Trial last updated 04/29/2016 - 12:40pm.

  10. How we treat higher-risk myelodysplastic syndromes

    ... hypomethylating agent therapy, induction chemotherapy or a clinical trial should be considered to prevent ...

    Research Article last updated 01/08/2014 - 8:57am.