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  1. Lack of objective response of myelodysplastic syndromes and acute myeloid leukemia to decitabine after failure of azacitidine

    ... leukemia (AML) unlikely to benefit from cytotoxic chemotherapy . Switching hypomethylating agents after treatment failure is ...

    Research Article last updated 10/02/2014 - 10:13am.

  2. Jill Whitney – Since my diagnosis, my mission has been to fight back

    ... not even recovered from my transplant and was now facing chemotherapy . I began receiving azacitidine (Vidaza®), but my ... of my stem cell transplant (re-birthday). I tolerate chemotherapy pretty well now and take medication to mitigate the side effects. ...

    Patient Chronicle last updated 05/26/2015 - 9:29am.

  3. Update on the pharmacotherapy for myelodysplastic syndromes

    ... relied upon supportive care and intensive chemotherapy . The last decade has seen many scientific and therapeutic ...

    Research Article last updated 08/21/2014 - 9:23am.

  4. Myelodysplastic syndromes

    ... in a third of patients. 15% of cases occur after chemotherapy or radiotherapy for a previous cancer; the syndromes are most ...

    Research Article last updated 04/16/2014 - 12:04pm.

  5. Clinical results with the DNA hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in patients with myelodysplastic syndromes: an update

    ... Due to their lower toxicity compared to conventional chemotherapy , hypomethylating agents are often a safe and feasible ... may play a role in epigenetic "priming" before conventional chemotherapy. This review summarizes the results of clinical trials and ...

    Research Article last updated 11/05/2012 - 9:34am.

  6. Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System.

    ... care without specific therapy, with AML-like chemotherapy , or with other therapy regimens (low-dose chemotherapy, demethylating agents, immune modulating agents, valproic acid, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Transplantation strategies for the management of patients with myelodysplastic syndromes.

    ... are almost equal with the results obtained by intensive chemotherapy alone. Failure was due primarily to TRM in patients with ... the procedure. Autologous SCT after successful induction chemotherapy may increase the proportion of long-term survivors, thus ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow

    ... patients with these diseases can be treated with medical chemotherapy alone. However, patients who relapse following chemotherapy are usually not curable with additional chemotherapy treatments. ...

    Clinical Trial last updated 04/28/2016 - 2:08pm.

  9. Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia

    ... of the enzymes needed for cell growth. Drugs used in chemotherapy , such as azacitidine , work in different ways to stop ... untreated AML, if not candidates for standard induction chemotherapy or with poor risk AML (i.e. preceding MDS, myeloproliferative ...

    Clinical Trial last updated 06/03/2016 - 2:24pm.

  10. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... high risk acute myeloid leukemia. Giving low doses of chemotherapy before a donor peripheral blood stem cell transplant ... to administration of 1st dose of remission induction chemotherapy ; if a bone marrow aspirate and biopsy were obtained within 28 ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.