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  1. Decitabine Followed by Mitoxantrone Hydrochloride, Etoposide, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

    ... or does not respond to treatment. Drugs used in chemotherapy , such as mitoxantrone hydrochloride, etoposide, cytarabine, ... them from spreading. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Status:  ...

    Clinical Trial last updated 04/28/2016 - 9:51am.

  2. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... myeloproliferative disorders (MPD). Giving low doses of chemotherapy , such as fludarabine phosphate, and total-body irradiation ... transplant helps stop the growth of cancer cells. Giving chemotherapy or radiation therapy before or after transplant also stops the ...

    Clinical Trial last updated 04/27/2016 - 1:27pm.

  3. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... if bone marrow transplantation (BMT) followed by chemotherapy will help people with aplastic anemia who have failed ... one or more immunosuppressive treatments. High dose chemotherapy followed by bone marrow transplantation (BMT) has been used to ...

    Clinical Trial last updated 04/21/2016 - 1:19pm.

  4. Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 (DFCI 10-106)

    ... also approved by the FDA. Melphalan is an FDA-approved chemotherapy for multiple myeloma and is used as a high-dose conditioning ...

    Clinical Trial last updated 05/23/2016 - 3:45pm.

  5. An Open-label Study of Lirilumab (BMS-986015) in Combination With 5-azacytidine (Vidaza) for the Treatment of Patients With Refractory/ Relapsed Acute Myeloid Leukemia

    ... be used for AML. Prior therapy with hydroxyurea, chemotherapy , biological or targeted therapy (e.g. FLT3 inhibitors, other ...

    Clinical Trial last updated 06/06/2016 - 1:26pm.

  6. A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)

    ... conditions that compromise the ability to give cytotoxic chemotherapy as the primary modality. Patients who decline cytotoxic chemotherapy. Patients with AML of age ≥ 60 years who have relapsed ...

    Clinical Trial last updated 06/03/2016 - 3:09pm.

  7. Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia or Acute Leukemia in Remission

    ... and symptoms of myelodysplasia or acute leukemia. Giving chemotherapy , such as clofarabine and melphalan, before a donor stem cell ...

    Clinical Trial last updated 05/03/2016 - 11:55am.

  8. Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia (VITAL)

    ... with untreated acute myeloid leukemia. Drugs used in chemotherapy , such as vosaroxin and cytarabine, work in different ways to ...

    Clinical Trial last updated 05/03/2016 - 11:51am.

  9. Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

    ... high-risk hematologic malignancies. Giving low-doses of chemotherapy and total-body irradiation before a donor stem cell transplant ...

    Clinical Trial last updated 05/03/2016 - 10:51am.

  10. A Phase II Study of 5-Azacitidine and Sargramostim as Maintenance Treatment After Definitive Therapy for Poor-risk AML or MDS

    ... cell transplant or cytarabine-based consolidation chemotherapy . In order to precede relapse and to avoid lead time bias, ...

    Clinical Trial last updated 05/03/2016 - 10:38am.