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  1. Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... multiple mechanisms. Panobinostat belongs to a class of chemotherapy drugs called "histone deacetylase (HDAC) inhibitors." HDAC ... causes them to die. Fludarabine and cytarabine are chemotherapy drugs that are commonly used to treat pediatric patients with ...

    Clinical Trial last updated 04/29/2016 - 10:11am.

  2. Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

    ... Purpose:  RATIONALE: Giving chemotherapy , such as busulfan, fludarabine , and melphalan, before ... This phase II trial is studying how well combination chemotherapy followed by a donor umbilical cord blood transplant works ...

    Clinical Trial last updated 04/29/2016 - 9:56am.

  3. Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive Chemotherapy

    ... of the enzymes needed for cell growth. Drugs used in chemotherapy , such as azacitidine, work in different ways to stop the ...

    Clinical Trial last updated 04/28/2016 - 1:13pm.

  4. Decitabine Followed by Mitoxantrone Hydrochloride, Etoposide, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

    ... or does not respond to treatment. Drugs used in chemotherapy , such as mitoxantrone hydrochloride, etoposide, cytarabine, ... them from spreading. Giving more than one drug (combination chemotherapy) may kill more cancer cells. ...

    Clinical Trial last updated 04/28/2016 - 9:51am.

  5. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... myeloproliferative disorders (MPD). Giving low doses of chemotherapy , such as fludarabine phosphate, and total-body irradiation ... transplant helps stop the growth of cancer cells. Giving chemotherapy or radiation therapy before or after transplant also stops the ...

    Clinical Trial last updated 04/27/2016 - 1:27pm.

  6. Chronic Lymphocytic Leukemia (CLL)

    ... CLL patients who are treated with certain types of chemotherapy have an increased risk of developing myelodysplastic ...

    Topic section last updated 07/07/2016 - 3:18pm.

  7. A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 Mutation (AML)

    ... FLT3+ AML and not eligible for standard induction chemotherapy or FLT3+ high-risk MDS/CMML (defined as ≥ 10% ... to prior therapy At least 4 weeks beyond the last chemotherapy, (or ≥ 2 weeks or ≥ 2 5 half- lives for targeted agents, ...

    Clinical Trial last updated 05/09/2016 - 4:09pm.

  8. Causes

    ... arsenic and benzene Radiation and chemotherapy used to treat cancer Treatments for other autoimmune ...

    Topic section last updated 06/30/2016 - 9:46am.

  9. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... if bone marrow transplantation (BMT) followed by chemotherapy will help people with aplastic anemia who have failed ... one or more immunosuppressive treatments. High dose chemotherapy followed by bone marrow transplantation (BMT) has been used to ...

    Clinical Trial last updated 04/21/2016 - 1:19pm.

  10. Chronic Myelomonocytic Leukemia (CMML)

    ... by increasing blood counts and stopping infections Chemotherapy to kill cells cancer cells using cytotoxic agents ...

    Topic section last updated 12/16/2016 - 9:42am.