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  1. Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies

    ... cells, which may cause the cancer cells to die. This chemotherapy is also designed to block your body's ability to reject the ... flow cytometry ), secondary leukemia from prior chemotherapy and/or arising from MDS, Langerhan's cell histiocytosis, any ...

    Clinical Trial last updated 06/06/2016 - 12:58pm.

  2. Phase I/II MEK162 Relapsed and/or Refractory Acute Myeloid Leukemia (AML) and Poor Prognosis, Not Suitable for or Unwilling to Receive Standard Therapy

    ... equal to 65 years of age), not candidates for intensive chemotherapy ; b. Subjects with MDS, IPSS Int-2 or high risk (RAEB-2 only, ... AML, as determined by known and documented exposure to chemotherapy or radiation therapy; ii. antecedent history of MDS or ...

    Clinical Trial last updated 06/06/2016 - 10:59am.

  3. T-cell Depleted Alternative Donor Transplantation

    ... patient will receive a conditioning regimen including chemotherapy drugs and/or total body irradiation based on the disease for ... remission but may be enrolled when aplastic after chemotherapy or with < 20% blasts. Patients with lymphoma must be in ...

    Clinical Trial last updated 04/29/2016 - 3:38pm.

  4. Multicenter Phase II of CD26 Using Sitagliptin for Engraftment After UBC Transplant

    ... start of preceding leukemia induction cytotoxic chemotherapy . For patients in remission, there should be no readily ... (CNS) involvement refractory to intrathecal chemotherapy . Prior allogeneic or autologous hematopoietic stem ...

    Clinical Trial last updated 06/06/2016 - 3:37pm.

  5. Total Marrow Irradiation for Refractory Acute Leukemia

    ... Purpose:  RATIONALE: Giving chemotherapy and total marrow irradiation before a donor umbilical cord ... marrow irradiation when given together with combination chemotherapy and umbilical cord blood hematopoietic stem cell transplant in ...

    Clinical Trial last updated 05/02/2016 - 9:22am.

  6. Multicenter Phase II of CD26 Using Sitagliptin for Engraftment After UBC Transplant

    ... start of preceding leukemia induction cytotoxic chemotherapy . For patients in remission, there should be no readily ... (CNS) involvement refractory to intrathecal chemotherapy . Prior allogeneic or autologous hematopoietic stem ...

    Clinical Trial last updated 06/03/2016 - 2:54pm.

  7. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... hematologic malignancies not curable by conventional chemotherapy . Responses to conventional treatment range from zero to 30% ... lymphoma, Hodgkin lymphoma and multiple myeloma with chemotherapy sensitive disease that has failed or patients who are ineligible ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  8. IPA Targeted Adoptive Immunotherapy vs Adult Haplo-identical Cell Infusion During Induction of High Risk Leukemia

    ... safety of adoptive immunotherapy when given after chemotherapy for AML/MDS. Adoptive immunotherapy means using an infusion of ... possibly because they hasten recovery of cell counts from chemotherapy. The Investigators are interested in confirming these data, but ...

    Clinical Trial last updated 04/29/2016 - 11:05am.

  9. Crenolanib in Combination With Sorafenib in Patients With Refractory or Relapsed Hematologic Malignancies

    ... 2 weeks have elapsed since prior systemic cytotoxic chemotherapy (except intrathecal chemotherapy, hydroxyurea, low-dose cytarabine, and/or low dose maintenance ...

    Clinical Trial last updated 06/06/2016 - 10:04am.

  10. Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... own immune system is prevented by giving low doses of chemotherapy ( fludarabine phosphate and cyclophosphamide) and ... remission (CR) High-risk MDS status-post cytotoxic chemotherapy Burkitt's lymphoma: second or subsequent CR ...

    Clinical Trial last updated 04/29/2016 - 3:26pm.