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  1. The myelodysplastic syndrome as a prototypical epigenetic disease.

    ... of apoptosis and eventual symptoms related to bone marrow failure . Cellular differentiation is an epigenetic process that ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... with a complement-mediated hemolytic anemia , bone marrow failure and a propensity for thrombosis . These patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... , renal impairment, pulmonary hypertension, and bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... hemolytic anemia , thrombophilia, and bone marrow failure . PNH is due to a somatic, acquired mutation in the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... that manifests with hemolytic anemia and bone marrow failure . Eculizumab has been shown to improve anemia, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Outcome of Pediatric Acquired Aplastic Anemia: A Developing World Experience.

    ... history, physical examination, complete blood count, bone marrow aspirate, and biopsy were retrieved for all children <18 years, with ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... of PNH include evidence of hemolytic anemia , bone marrow failure , smooth muscle dystonias and thromboses. Treatment options ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Eltrombopag in aplastic anemia

    ... is evidence that this drug works by directly stimulating marrow stem and progenitor cells thereby promoting hematopoietic recovery in patients with bone marrow failure . Several trials are ongoing in our institution using ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... and organismal aging as well as in tumorigenesis. Bone marrow failure and malignancy are 2 life-threatening disease manifestations ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Immunomodulatory treatment of myelodysplastic syndromes: antithymocyte globulin, cyclosporine, and alemtuzumab

    ... MDS might share with SAA an autoimmune basis for the bone marrow failure common to both conditions. The idea was supported by reports ...

    Research Article last updated 07/20/2018 - 5:14pm.