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  1. Myelodysplastic syndromes: 2011 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... RISK-ADAPTED THERAPY: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts and more recently cytogenetic ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders.

    ... Journal Title:  Blood Primary Author:  ... P=0.005). Multivariate analysis including age, IPSS, transfusion dependence, ASXL1, CBL, RUNX1, TEL/ETV6, and TP53 mutation status ...

    Research Article last updated 07/29/2014 - 12:11pm.

  3. Molecular pathogenesis of myelodysplastic syndromes

    ... , hypercellular bone marrow , dysplasia of blood cells and cytopenias. Most patients are diagnosed in their late 60s to ... decitabine , and 5-azacytidine, are targeted to improve transfusion requirements and quality of life. Moreover, 5-azacytidine has also ...

    Research Article last updated 05/22/2014 - 10:05am.

  4. Clinical and genetic predictors of prognosis in myelodysplastic syndromes

    ... Most models include the presence or severity of peripheral blood cytopenias, the proportion of bone marrow blasts , and ... factors including age, performance status, co-morbidities, transfusion dependence, and molecular biomarkers can further refine the ...

    Research Article last updated 06/19/2014 - 1:30pm.

  5. Comparison of Rabbit Antithymocyte Globulin (R-ATG) and Jurkat Cell-Reactive Anti-T Lymphocyte Globulin (ATG-F) as a First-line Treatment for Children with Aplastic Anemia

    ... AA (SAA), 10 cases of very severe AA (VSAA) and 11 cases of transfusion-dependent non-severe AA (NSAA). While receiving immunosuppressive ... and/or infection control. Absolute counts of peripheral blood lymphocyte (ALC) in various time points were dynamically measured after ...

    Research Article last updated 04/09/2014 - 9:23am.

  6. Costs and quality of life in patients with myelodysplastic syndromes.

    ... Journal Title:  Am J Blood Res Primary Author:  ... and the impact on quality of life (QOL) of MDS-separately in transfusion-independent (TI) and -dependent (TD) patients-a literature search ...

    Research Article last updated 09/16/2013 - 8:45am.

  7. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... The purpose of this study was to observe the outcome of co-transfusion of umbilical cord multipotent stromal cells (UC-MSC) and allogeneic ... factor-primed bone marrow and peripheral blood grafts; the other patients received granulocyte colony-stimulating ...

    Research Article last updated 07/09/2013 - 2:48pm.

  8. Iron overload in myelodysplastic syndromes: diagnosis and management.

    ... stem cell malignancies characterized by ineffective blood cell production. Many MDS patients are dependent on red blood cell ... MDS whose expected survival is measured in years. Transfusion dependence is associated with shorter survival and an increased ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... Journal Title:  Pediatr Blood Cancer Primary Author:  ... hemoglobin and platelet levels as triggers for transfusion support; the use of prophylactic antibiotics; and follow-up ...

    Research Article last updated 12/17/2013 - 8:30am.

  10. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... factor-mobilized bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral ... no chronic GvHD was documented. All patients were alive and transfusion independent at a median follow-up of 15 months (range: 6-29 ...

    Research Article last updated 07/30/2012 - 1:18pm.