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  1. Optimizing therapy for iron overload in the myelodysplastic syndromes: recent developments.

    ... leukaemia (AML). Most MDS patients eventually require transfusion of red blood cells for anaemia, placing them at risk of transfusional iron ... patients may have improvement in cell counts and decreased transfusion requirements. While guidelines for MDS generally recommend ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... Risk-adapted therapy: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts, and, more recently, ...

    Research Article last updated 07/31/2012 - 2:02pm.

  3. Myelodysplastic syndromes: 2011 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... RISK-ADAPTED THERAPY: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts and more recently cytogenetic ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Costs and quality of life in patients with myelodysplastic syndromes.

    Journal Title:  Am J Blood Res Primary Author:  ... and the impact on quality of life (QOL) of MDS-separately in transfusion-independent (TI) and -dependent (TD) patients-a literature search ...

    Research Article last updated 09/16/2013 - 8:45am.

  5. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    Journal Title:  Pediatr Blood Cancer Primary Author:  ... hemoglobin and platelet levels as triggers for transfusion support; the use of prophylactic antibiotics; and follow-up ...

    Research Article last updated 12/17/2013 - 8:30am.

  6. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... The purpose of this study was to observe the outcome of co-transfusion of umbilical cord multipotent stromal cells (UC-MSC) and allogeneic ... factor-primed bone marrow and peripheral blood grafts; the other patients received granulocyte colony-stimulating ...

    Research Article last updated 07/09/2013 - 2:48pm.

  7. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... factor-mobilized bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral ... no chronic GvHD was documented. All patients were alive and transfusion independent at a median follow-up of 15 months (range: 6-29 ...

    Research Article last updated 07/30/2012 - 1:18pm.

  8. Iron overload in myelodysplastic syndromes: diagnosis and management.

    ... stem cell malignancies characterized by ineffective blood cell production. Many MDS patients are dependent on red blood cell ... MDS whose expected survival is measured in years. Transfusion dependence is associated with shorter survival and an increased ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Supportive care in severe and very severe aplastic anemia

    ... early treatment of fungal, bacterial and viral infections, transfusion strategy and iron chelation and assess the evidence basis. In fact, ... infections and of secondary events like alloimmunization to blood products and iron overload have a significant impact on the ...

    Research Article last updated 01/02/2013 - 2:32pm.

  10. Therapeutic modalities for patients with lower-risk myelodysplastic syndromes: current options and future directions.

    ... goals of treatment include improvement of peripheral blood cytopenias, reduction of transfusions, improvement of the quality of ... , warrants treatment in an attempt to eliminate transfusion dependence. This article reviews current treatment strategies for ...

    Research Article last updated 10/11/2011 - 5:58pm.