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  1. Can iron overload in patients with lower-risk myelodysplastic syndromes be reduced using erythropoiesis-stimulating agents?

    ... Erythropoiesis-stimulating agents (ESA) may reduce red blood cell transfusion requirements. MDS patients receiving ESA were reviewed for ...

    Research Article last updated 12/09/2015 - 8:52am.

  2. Infections in myelodysplastic syndromes: a review

    ... by transiently worsening the pre-existing low white blood cell (WBC) counts. However, this increased risk of infections ... and liver disease and particularly those with greater transfusion needs are most vulnerable to infections. Available data from two ...

    Research Review last updated 05/02/2016 - 9:28am.

  3. Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation

    ... HLA -identical sibling donor peripheral blood stem cell (PBSC) transplantation for the treatment of a high risk ... syndrome with severe pancytopenia , leading to either transfusion dependency or increased risk for infections Performance ...

    Clinical Trial last updated 04/29/2016 - 1:48pm.

  4. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... of using a system called CliniMACS to remove Tcells from blood stem cells . Removing T-cells may help stop a side effect called ... (MDS): RA//RARS/RCMD with high risk cytogenetic features or transfusion dependence as well as RAEB-1 and RAEB-2 and Acute myelogenous ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  5. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... is approved for the treatment of patients who have transfusion-dependent anemia due to lower-risk MDS with chromosome 5q ... that lenalidomide is effective not only in reducing red blood cell (RBC) transfusion burden, but also in modifying the disease ...

    Research Article last updated 12/08/2015 - 1:06pm.

  6. Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

    ... recover faster following a stem cell transplant . Blood stem cells are very young blood cells that grow in the body to ... (MDS): RA/RCMD with high risk cytogenetic features or transfusion dependence, RAEB-1 and RAEB-2 Chronic myelomonocytic leukemia: ...

    Clinical Trial last updated 04/29/2016 - 1:11pm.

  7. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... are partial, with only a few patients achieving normal blood counts. Furthermore, analysis of our own extensive clinical data suggests ... to a single course of ATG (non-robust responders), even when transfusion-independence is achieved, predicts a worse prognosis than when ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  8. Iron Overload and MDS

    ... Anemia , having low number of red blood cells (RBC), affects 80% of patients with MDS, with a substantial ... a short period of time. The amount of iron in a single RBC transfusion is the same as 1,280 cups of cooked spinach. The buildup of iron in ...

    Research Review last updated 05/02/2016 - 9:18am.

  9. Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

    ... stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy and radiation ... (RA) or all IPSS categories if severe pancytopenia , transfusion requirements not responsive to therapy, or high risk ...

    Clinical Trial last updated 05/02/2016 - 2:20pm.

  10. Allo HSCT Using RIC for Hematological Diseases

    ... < 0.8, Anemia or thrombocytopenia requiring transfusion; Poor or very poor risk cytogenetics based on IPSS or R-IPSS ... to a fetus. Females of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out ...

    Clinical Trial last updated 05/02/2016 - 9:29am.