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  1. Prognostic value of self-reported fatigue on overall survival in patients with myelodysplastic syndromes: a multicentre, prospective, observational, cohort study

    ... with reduced overall survival were increasing age, transfusion dependency (defined as having received at least one red blood cell transfusion every 8 weeks over a period of 4 months), Eastern ...

    Research Article last updated 11/10/2015 - 10:47am.

  2. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... is approved for the treatment of patients who have transfusion-dependent anemia due to lower-risk MDS with chromosome 5q ... that lenalidomide is effective not only in reducing red blood cell (RBC) transfusion burden, but also in modifying the disease ...

    Research Article last updated 12/08/2015 - 1:06pm.

  3. Clinical utility of lenalidomide in the treatment of myelodysplastic syndromes

    ... Journal Title:  J Blood Med Primary Author:  ... del(5q) MDS, including reduction in red blood cell transfusion requirements and improvements in quality of life. Lenalidomide has ...

    Research Article last updated 03/02/2015 - 2:11pm.

  4. Myelodysplastic syndromes and the role of iron overload.

    ... in patients with MDS due to the long-term use of red blood cell transfusions in patients with symptomatic anemia . ... options for patients with MDS do not always reduce the transfusion burden, many patients will still need long-term transfusion ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

    ... months (range 6-46 months). Parameters of hemolysis , transfusion requirements, and serum iron parameters were analyzed. Lactate ... low reticulocyte production index and/or requiring blood transfusions. Monospecific direct Coombs test was positive in most PNH ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... Risk-adapted therapy: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts and more recently cytogenetic ...

    Research Article last updated 02/04/2014 - 1:37pm.

  7. Azacitidine in the management of patients with myelodysplastic syndromes.

    ... of treatment for MDS was supportive care , including transfusion of blood products and growth factors. Further understanding of disease biology led ...

    Research Article last updated 05/14/2013 - 2:48pm.

  8. Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes.

    ... Transfusion dependency and iron overload are common among patients with ... myelodysplastic syndromes (MDS) treated with red blood cell (RBC) transfusions. Transfusion dependency is associated with ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Optimizing therapy for iron overload in the myelodysplastic syndromes: recent developments.

    ... leukaemia (AML). Most MDS patients eventually require transfusion of red blood cells for anaemia, placing them at risk of transfusional iron ... patients may have improvement in cell counts and decreased transfusion requirements. While guidelines for MDS generally recommend ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... Risk-adapted therapy: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts, and, more recently, ...

    Research Article last updated 07/31/2012 - 2:02pm.