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  1. Jeff Paccione: “Don’t worry, I’m not going anywhere.”

    ... on Jeff’s retinas, he immediately told Jeff to get blood work and so we rushed to his doctor.   The 7:00 a.m. phone call the ... waiting room before Jeff received platelets and a blood transfusion , he leaned over to me and quietly assured me, “Don’t worry, ...

    Patient Chronicle last updated 05/23/2017 - 10:40am.

  2. Myelodysplastic syndromes and the role of iron overload.

    ... in patients with MDS due to the long-term use of red blood cell transfusions in patients with symptomatic anemia . ... options for patients with MDS do not always reduce the transfusion burden, many patients will still need long-term transfusion ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

    ... months (range 6-46 months). Parameters of hemolysis , transfusion requirements, and serum iron parameters were analyzed. Lactate ... low reticulocyte production index and/or requiring blood transfusions. Monospecific direct Coombs test was positive in most PNH ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... Risk-adapted therapy: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts and more recently cytogenetic ...

    Research Article last updated 02/04/2014 - 1:37pm.

  5. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders.

    Journal Title:  Blood Primary Author:  Damm F ... P=0.005). Multivariate analysis including age, IPSS, transfusion dependence, ASXL1, CBL, RUNX1, TEL/ETV6, and TP53 mutation status ...

    Research Article last updated 07/29/2014 - 12:11pm.

  6. Clinical and genetic predictors of prognosis in myelodysplastic syndromes

    ... Most models include the presence or severity of peripheral blood cytopenias, the proportion of bone marrow blasts , and ... factors including age, performance status, co-morbidities, transfusion dependence, and molecular biomarkers can further refine the ...

    Research Article last updated 06/19/2014 - 1:30pm.

  7. Molecular pathogenesis of myelodysplastic syndromes

    ... , hypercellular bone marrow , dysplasia of blood cells and cytopenias. Most patients are diagnosed in their late 60s to ... decitabine , and 5-azacytidine, are targeted to improve transfusion requirements and quality of life. Moreover, 5-azacytidine has also ...

    Research Article last updated 05/22/2014 - 10:05am.

  8. Azacitidine in the management of patients with myelodysplastic syndromes.

    ... of treatment for MDS was supportive care , including transfusion of blood products and growth factors. Further understanding of disease biology led ...

    Research Article last updated 05/14/2013 - 2:48pm.

  9. Comparison of Rabbit Antithymocyte Globulin (R-ATG) and Jurkat Cell-Reactive Anti-T Lymphocyte Globulin (ATG-F) as a First-line Treatment for Children with Aplastic Anemia

    ... AA (SAA), 10 cases of very severe AA (VSAA) and 11 cases of transfusion-dependent non-severe AA (NSAA). While receiving immunosuppressive ... and/or infection control. Absolute counts of peripheral blood lymphocyte (ALC) in various time points were dynamically measured after ...

    Research Article last updated 04/09/2014 - 9:23am.

  10. Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes.

    ... February 12, 2011 Transfusion dependency and iron overload are common among patients with ... myelodysplastic syndromes (MDS) treated with red blood cell (RBC) transfusions. Transfusion dependency is associated with ...

    Research Article last updated 10/11/2011 - 5:58pm.