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  1. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... thrombopoietin mimetic eltrombopag (Promacta) can improve blood counts. Twenty-five patients received eltrombopag at a dose of 50 mg, ... were clinically significant changes in blood counts or transfusion independence . Patients with a response continued to receive ...

    Research Article last updated 07/31/2012 - 2:24pm.

  2. Long term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.

    Journal Title:  Blood Primary Author:  Kelly RJ ... (66%) patients on treatment for over 12 months achieved transfusion independence on eculizumab. The mean transfusion requirement ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... gene, which impairs the membrane expression on affected blood cells of a number of proteins, including the complement regulators CD55 ... leading to hemoglobin stabilization and transfusion independence in more than half of the patients. However, recent ...

    Research Article last updated 03/05/2013 - 9:38am.

  4. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... gene, which impairs the membrane expression on affected blood cells of a number of proteins, including the complement regulators CD55 ... leading to hemoglobin stabilization and transfusion independence in more than half of the patients. However, recent ...

    Research Article last updated 10/02/2012 - 9:57am.

  5. Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia

    ... to 20%. Oral and SC azacitidine decreased DNA methylation in blood, with maximum effect at day 15 of each cycle. Hematologic responses ... remission, hematologic improvement, or RBC or platelet transfusion independence) was 35% in previously treated patients and 73% in ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Blood Transfusion Safety and Risks

    Negative side effects of blood transfusion therapy are uncommon. Blood banks, hospitals, and health-care providers take many precautions to ...

    Page last updated 10/31/2014 - 2:36pm.

  7. Clinical utility of lenalidomide in the treatment of myelodysplastic syndromes

    Journal Title:  J Blood Med Primary Author:  Abou ... del(5q) MDS, including reduction in red blood cell transfusion requirements and improvements in quality of life. Lenalidomide has ...

    Research Article last updated 03/02/2015 - 2:11pm.

  8. Eltrombopag Added to IST Yields Encouraging Results

    ... we had only hoped eltrombopag would improve the platelet transfusion frequency in patients who had not adequately responded to ... in platelet counts but also noticed recovering red and white blood cells numbers. Although the magnitude of the response was somewhat ...

    Interview last updated 05/24/2017 - 7:44am.

  9. Jill Whitney – Since my diagnosis, my mission has been to fight back

    ... setbacks that kept me in isolation longer than expected. A blood infection (sepsis) sent me to the ICU for three days. I watched the days ... completed my 34th cycle of azacitidine and have not needed a transfusion in over 2 1/2 years. It has now been four years since my relapse, ...

    Patient Chronicle last updated 05/26/2015 - 9:29am.

  10. AAMDSIF Summer Fellowship Grant Program

    ... (BM) characterized by profound decrease of the number of red blood cells, white blood cells, and platelets in the blood stream, leading to ... the elderly. Currently, treatment includes blood transfusion to treat the anemia, and toxic chemotherapies that can deepen ...

    Page last updated 05/17/2017 - 1:29pm.