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  1. Iron Overload and MDS

    ... Anemia , having low number of red blood cells (RBC), affects 80% of patients with MDS, with a substantial ... a short period of time. The amount of iron in a single RBC transfusion is the same as 1,280 cups of cooked spinach. The buildup of iron in ...

    Research Review last updated 05/02/2016 - 9:18am.

  2. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... regimen plus a CD34+ selected T-cell depleted peripheral blood stem cell (PBSC) stem cell transplant for the treatment of ... with Fanconi anemia presenting with severe marrow failure (transfusion dependent) or myelodysplastic syndrome, or acute myelogenous ...

    Clinical Trial last updated 04/28/2016 - 8:44am.

  3. Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

    ... of a specific kind of transplant. In this transplant, blood from two donors will be used. Each donor will share one half of your HLA ... (MDS): RA/RCMD with high risk cytogenetic features or transfusion dependence, RAEB-1 and RAEB-2 and Acute myelogenous leukemia ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.

  4. Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

    ... stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy and radiation ... (RA) or all IPSS categories if severe pancytopenia , transfusion requirements not responsive to therapy, or high risk ...

    Clinical Trial last updated 05/02/2016 - 2:20pm.

  5. A Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia (LeucineDBA)

    ... form of a capsule and will be taken three times daily. Blood hemoglobin levels will be monitored every 3-4 weeks for 9 months. ... Subjects must be two years of age or older and on transfusion for more than six months prior to enrollment. ...

    Clinical Trial last updated 04/28/2016 - 8:40am.

  6. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... after transplant. Eligibility: - Adults 18 70 with blood or bone marrow cancer with no HLA-matched sibling, but with a ... risk: Hemoglobin < 10 g/dl, or > 10 g/dl with transfusion dependence. WBC < 4,000 or > 30,000/mm3 or requires ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  7. UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep

    ... according to current University of Minnesota umbilical cord blood graft selection algorithm. Status:  ... Severe Cytopenias: ANC < 0.8, PRBC or platelets requiring transfusion; Higher risk cytogenetics based on IPSS or R-IPSS definitions; ...

    Clinical Trial last updated 04/29/2016 - 10:06am.

  8. Allo HSCT Using RIC for Hematological Diseases

    ... < 0.8, Anemia or thrombocytopenia requiring transfusion; Poor or very poor risk cytogenetics based on IPSS or R-IPSS ... to a fetus. Females of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  9. RIC Transplant Using Haplo Donors

    ... greater; neutropenia or cytopenia requiring transfusion not responding to therapy; peripheral or BM blast count of <10%; ... Day 4. Other Name: Cytoxan Procedure: peripheral blood stem cell transplant Other Name: HSCT ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  10. MDS Drug Therapy

    ... sub-types of MDS Lenalidomide (Revlimid®) for transfusion-dependent MDS patients with isolated del(5q) and with a low or ... had some positive response to treatment, meaning that blood counts went up. The percentage of patients still surviving after two ...

    Topic section last updated 03/10/2016 - 11:26pm.