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  1. MDS Patient Becomes a Role Model

    ... and things became very serious. Because the MDS affected our blood counts, and in turn our immune systems, we both caught rare infections ... centers, and nursing homes. She has to get a blood transfusion about once a week now. Because everything happened so suddenly, ...

    Patient Chronicle last updated 04/22/2016 - 5:19pm.

  2. Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation

    ... HLA -identical sibling donor peripheral blood stem cell (PBSC) transplantation for the treatment of a high risk ... syndrome with severe pancytopenia , leading to either transfusion dependency or increased risk for infections Performance ...

    Clinical Trial last updated 04/29/2016 - 1:48pm.

  3. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... of using a system called CliniMACS to remove Tcells from blood stem cells . Removing T-cells may help stop a side effect called ... (MDS): RA//RARS/RCMD with high risk cytogenetic features or transfusion dependence as well as RAEB-1 and RAEB-2 and Acute myelogenous ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  4. Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

    ... recover faster following a stem cell transplant . Blood stem cells are very young blood cells that grow in the body to ... (MDS): RA/RCMD with high risk cytogenetic features or transfusion dependence, RAEB-1 and RAEB-2 Chronic myelomonocytic leukemia: ...

    Clinical Trial last updated 04/29/2016 - 1:11pm.

  5. Infections in myelodysplastic syndromes: a review

    ... by transiently worsening the pre-existing low white blood cell (WBC) counts. However, this increased risk of infections ... and liver disease and particularly those with greater transfusion needs are most vulnerable to infections. Available data from two ...

    Research Review last updated 05/02/2016 - 9:28am.

  6. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... Severe aplastic anemia (SAA) is a life-threatening blood disease that can be successfully treated with immunosuppressive drug ... 7 eventually became tri-lineage responders. Nine became transfusion-independent for platelets (median increase in platelet count ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  7. FAQs

    ... anemia happens when your bone marrow stops making enough blood-forming stem cells . Most experts believe aplastic anemia occurs ... counts go up you are less likely to need blood from a donor (transfusion), your quality of life becomes better and your symptoms are not as ...

    Topic section last updated 03/02/2016 - 11:42am.

  8. Duane Draper builds supportive community to help him with MDS and bone marrow transplant

    ... during a  physical, his physician did some routine blood work and discovered that all three of his blood counts were low. ... bleeding gums, for which he required his first platelet transfusion . Continuing drops in hemoglobin levels necessitated a ...

    Patient Chronicle last updated 09/09/2014 - 10:02am.

  9. “Mom, it’s too late. I’m dying.”

    ... Immediately, I got him to the doctor, and he was sent for blood work. He went to his grandmother’s to lay down while I was at work.  ... his blood counts to come back up. Jake continued to be transfusion dependent, and we returned to Boston for another bone marrow ...

    Patient Chronicle last updated 04/26/2016 - 11:43am.

  10. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... compared to filgrastim (G-CSF) mobilized peripheral blood stem cell (PBSC) transplants, BM allografts have lower CD34+ progenitor ... thrombosis , and/or cytopenia , and/or transfusion dependence and/or recurrent and debilitating hemolytic crisis ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.