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  1. What does it mean when my doctor says I have had a partial response to a drug treatment?

    ... no blast cells in the blood and a normal number of blasts cells in the bone marrow. A partial response is less than a ...

    FAQ last updated 03/15/2016 - 11:47pm.

  2. What is AML?

    ... your bone marrow being young white blood cells ( blasts ). About 30 out of 100 people with MDS will develop AML. Certain ...

    FAQ last updated 03/15/2016 - 11:27pm.

  3. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of thrombopoietin receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... bone marrow cells, such as leukemic precursor cells or blasts to proliferate and worsen the disease. Careful studies have ... Eltrombopag does not seem to stimulate leukemia blasts based on studies performed on patients’ bone marrow cells in the ...

    Research Review last updated 05/02/2016 - 9:21am.

  4. MDS is a Complicated Group of Disorders

    ... cases MDS progresses from lower- risk to higher-risk as blasts (immature white blood cells) increase in the bone marrow .  When the percentage of blasts reaches 20% or more, the patient is diagnosed as having acute ...

    Page last updated 06/27/2012 - 1:51pm.

  5. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... is most common in refractory anemia with excess blasts (RAEB) and chronic myelomonocytic leukemia (CMML). Sweet’s ...

    Research Review last updated 05/02/2016 - 9:18am.

  6. A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 Mutation (AML)

    ... MDS/CMML (defined as ≥ 10% peripheral blood or marrow blasts and international Prognostic Scoring System [IPSS] score ≥ ...

    Clinical Trial last updated 05/09/2016 - 4:09pm.

  7. T-cell Depleted Alternative Donor Transplantation

    ... leukemia must be in morphological remission (< 5% blasts ) at the time of transplant. Patients with acute non-lymphocytic ... when aplastic after chemotherapy or with < 20% blasts. Patients with lymphoma must be in complete or close to complete ...

    Clinical Trial last updated 04/29/2016 - 3:38pm.

  8. Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation

    ... by hematological recovery (ANC > 0.5x 109/L), AND <5% blasts by light microscopy within the bone marrow with a ... by hematological recovery (ANC > 0.5x 109/L), AND <5% blasts by light microscopy within the bone marrow with a cellularity of ≥15%. ...

    Clinical Trial last updated 04/29/2016 - 1:48pm.

  9. Prior allogeneic transplant Karnofsky Performance Score < 70% Active central nervous system (CNS) involvement by malignant cells Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progre

    ... example, myelodysplastic syndrome, bone marrow blasts > 5% or biphenotypia) Note: Patients with a history of prolonged ...

    Clinical Trial last updated 06/06/2016 - 2:05pm.

  10. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... limited only to those who have significant increase in blasts (leukemia cells), a complex cytogenetic (chromosomal) abnormality or ... overlap syndrome, when the criteria for MDS is excess blasts, complex cytogenetic abnormalities, or monosomy7 with lack of response ...

    Interview last updated 05/14/2015 - 1:53pm.