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  1. Clofarabine in the treatment of myelodysplastic syndromes

    ... DNA synthesis and can reduce the percentage of leukemic blasts in adult patients with MDS and acute myeloid leukemia (AML).  Early ...

    Research Review last updated 05/02/2016 - 9:18am.

  2. Vosaroxin for Intermediate 2 or High-risk MDS After Failure With Hypomethylating Agent-based Therapy

    ... confirmed Myelodysplastic Syndrome, or MDS, (< 20% blasts in bone marrow , peripheral blood, or both) by World Health ...

    Clinical Trial last updated 04/29/2016 - 1:36pm.

  3. A Combination Study of PF-04449913 and Azacitidine In 1st Line MDS, AML and CMML Patients

    ... (MDS), Acute Myeloid Leukemia (AML) with 20-30% blasts and multi lineage dysplasia, and Chronic Myelomonocytic Leukemia ...

    Clinical Trial last updated 04/27/2016 - 1:20pm.

  4. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of thrombopoietin receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... bone marrow cells, such as leukemic precursor cells or blasts to proliferate and worsen the disease. Careful studies have ... and risks. Eltrombopag does not seem to stimulate leukemia blasts based on studies performed on patients’ bone marrow cells in the ...

    Research Review last updated 05/02/2016 - 9:21am.

  5. Prior allogeneic transplant Karnofsky Performance Score < 70% Active central nervous system (CNS) involvement by malignant cells Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progre

    ... example, myelodysplastic syndrome, bone marrow blasts > 5% or biphenotypia) Note: Patients with a history of prolonged ...

    Clinical Trial last updated 06/06/2016 - 2:05pm.

  6. MDS - Basics

    ... Blast Counts Blasts are very young or immature white blood cells. In normal bone marrow , no more than 5 out of 100 white cells are blasts. Because people with MDS may have too many bone marrow blasts, doctors ...

    Topic section last updated 04/06/2016 - 1:22pm.

  7. Clone of Myelodysplastic Syndromes (MDS)

    ... Blast Counts Blasts are very young or immature white blood cells. In normal bone marrow , no more than 5 out of 100 white cells are blasts. Because people with MDS may have too many bone marrow blasts, doctors ...

    Page last updated 04/05/2016 - 3:56pm.

  8. A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 Mutation (AML)

    ... MDS/CMML (defined as ≥ 10% peripheral blood or marrow blasts and international Prognostic Scoring System [IPSS] score ≥ ...

    Clinical Trial last updated 05/09/2016 - 4:09pm.

  9. MDS—The Past 40 Years. A Look at the Emerging Awareness and Classification of Myelodysplastic Syndromes.

    ... CMML) and refractory anemia with excess blasts (RAEB) that could be confused with acute leukemia. These conditions ... until the end of the century. Based on the percentage of blasts (young, immature blood cells) in bone marrow and blood, the FAB ...

    Page last updated 10/19/2015 - 2:29pm.

  10. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... is most common in refractory anemia with excess blasts (RAEB) and chronic myelomonocytic leukemia (CMML). Sweet’s ...

    Research Review last updated 05/02/2016 - 9:18am.