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  1. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... We propose to enroll patients with MDS who have excess blasts (5% to 30% BM blasts), and have progressed during, failed to respond to, are intolerant of, ...

    Clinical Trial last updated 11/29/2016 - 8:29am.

  2. Myelodysplastic syndromes: Contemporary review and how we treat

    ... peripheral blood and bone marrow dysplasia/ blasts , and clonal cytogenetic abnormalities. With the advent of next ...

    Research Article last updated 04/29/2016 - 1:05pm.

  3. Oral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... in many countries for the treatment of AML with 20%-30% blasts and multilineage dysplasia according to the World Health ... of azacitidine treatment of patients with AML with >30% blasts have also been shown in a recent phase III trial. Oral administration of ...

    Research Article last updated 12/09/2015 - 8:49am.

  4. Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy

    ... with refractory anemia with excess blasts -1, -2, or, -t myelodysplastic syndromes (MDS) following ... addition, 15 patients achieved stabilization of bone marrow blasts. One patient with a complete bone marrow response also achieved a ...

    Research Article last updated 05/22/2014 - 10:23am.

  5. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine.

    ... 20%, RAEB-2 in 54%, and RAEB-t (AML with 21%-30% marrow blasts ) in 22%. Cytogenetic risk was good in 31%, intermediate in 17%, and ... arabinoside treatment (P = .009), bone marrow blasts > 15% (P = .004), and abnormal karyotype (P = .03) independently ...

    Research Article last updated 07/28/2014 - 8:53am.

  6. The Myelodysplastic Syndromes (MDS): A personal recollection of four decades of classification and prognostic scoring systems.

    ... namely refractory anemia with excess blasts (RAEB) and chronic myelomonocytic leukemia (CMML). Subsequent ... of the degrees of morphologic dysplasia and percentage of blasts have enhanced the classification. Several prognostic scoring systems ...

    Research Article last updated 05/14/2013 - 2:59pm.

  7. A Meta-Analysis of the Relationship between Cigarette Smoking and Incidence of Myelodysplastic Syndromes.

    ... with ringed sideroblasts (RARS) or RA with excess blasts (RAEB)/RAEB in transformation (RAEBt), respectively. Our results ...

    Research Article last updated 04/29/2016 - 12:57pm.

  8. Retrospective Analysis of Prognostic Factors Associated With Response and Overall Survival by Baseline Marrow Blast Percentage in Patients With Myelodysplastic Syndromes Treated With Decitabine.

    ... definition of acute myeloid leukemia (AML) to ≥ 20% blasts , the International Working Group (IWG) response criteria for ... with myelodysplastic syndrome (MDS) with baseline marrow blasts ≥ 20% and < 30% (RAEB-t group) and < 20% (MDS group) were compared. ...

    Research Article last updated 06/28/2013 - 1:20pm.

  9. Effectiveness and safety of different azacitidine dosage regimens in patients with myelodysplastic syndromes or acute myeloid leukemia

    ... acute myeloid leukemia with 20-30% bone marrow blasts . Patients were treated with azacitidine, with one of three dosage ...

    Research Article last updated 05/22/2014 - 9:28am.

  10. Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management

    ... analysis of peripheral cytopenias, percentage of blasts in the bone marrow and cytogenetic characteristics. The most ... based on risk, transfusion needs, percent of bone marrow blasts and more recently cytogenetic profile. Goals of therapy are different ...

    Research Article last updated 02/04/2014 - 1:37pm.