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  1. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... status, organ function, prior transplantation, hematopoietic cell transplant comorbidity index (HCT-CI)23, and CB TNC dose into those who ... Any acute leukemia (including prior myelodysplasia or CML blast crisis) with morphologic relapse or persistent disease ≥ 10% blasts ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  2. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... correctable by transplant for which CD34+ selected, T-cell depleted allogeneic hematopoietic stem cell transplantation is indicated ... second chronic phase or in CR after accelerated phase or blast crisis. Non-Hodgkins lymphoma with chemoresponsive disease in any ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  3. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... strategies to augment the well documented effect of NK cell alloreactivity seen in HLA -mismatched transplantation. These ... to tyrosine kinase inhibitors (OR) accelerated phase (OR) blast crisis in 2nd chronic phase following induction chemotherapy ) ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  4. Phase I/II, Study of Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) + Sorafenib in Acute Myeloid Leukemia

    ... therapy with up to two prior salvage regimens (SCT or stem cell therapy for patients who previously underwent SCT/stem cell therapy in ... with absorption of oral medications. Patients who are in blast transformation of chronic myeloid leukemia (CML). Prior MDS or CMML is ...

    Clinical Trial last updated 05/23/2016 - 3:37pm.

  5. FAQs

    ... MDS, you must have low blood counts for at least one blood cell type and your blood cells must look abnormal under a microscope. Doctors ... patients being treated for MDS, this might also include no blast cells in the blood and a normal number of blasts cells in the ...

    Topic section last updated 03/02/2016 - 11:42am.

  6. MDS: Diagnosis

    ... or CBC for short. The CBC measures the number of each blood cell type in your blood sample. If the CBC shows a low number of red blood ... of every 100 white blood cells in your bone marrow is a blast cell , this is not normal Damaged chromosomes (DNA) in ...

    Page last updated 01/20/2015 - 4:42pm.

  7. Understanding Prognosis in MDS

    ... may suggest a more risky therapy, such as a stem cell transplant , be tried. A better prognosis that indicates a longer life ... It’s difficult to tell a cancerous immature cell or blast from a healthy normal one. So if there are too many immature cells in the ...

    Interview last updated 05/02/2012 - 4:36pm.