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  1. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... status, organ function, prior transplantation, hematopoietic cell transplant comorbidity index (HCT-CI)23, and CB TNC dose into those who ... Any acute leukemia (including prior myelodysplasia or CML blast crisis) with morphologic relapse or persistent disease ≥ 10% blasts ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  2. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... correctable by transplant for which CD34+ selected, T-cell depleted allogeneic hematopoietic stem cell transplantation is indicated ... second chronic phase or in CR after accelerated phase or blast crisis. Non-Hodgkins lymphoma with chemoresponsive disease in any ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  3. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... strategies to augment the well documented effect of NK cell alloreactivity seen in HLA -mismatched transplantation. These ... to tyrosine kinase inhibitors (OR) accelerated phase (OR) blast crisis in 2nd chronic phase following induction chemotherapy ) ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  4. Treatments

    ... change over time. As blood counts go lower and bone marrow blast counts rise, your doctor will discuss other treatment options. ... marrow failure diseases to help increase red blood cell , white blood cell or platelet counts. ...

    Topic section last updated 03/30/2016 - 3:13pm.

  5. MDS - Treatment (OLD)

    ... change over time. As blood counts go lower and bone marrow blast counts rise, your doctor will discuss other treatment options. ... May or may not need blood transfusions, depending on blood cell counts Have a low or intermediate-1 risk IPSS score, which is between ...

    Topic section last updated 03/10/2016 - 11:01pm.

  6. FAQs

    ... MDS, you must have low blood counts for at least one blood cell type and your blood cells must look abnormal under a microscope. Doctors ... patients being treated for MDS, this might also include no blast cells in the blood and a normal number of blasts cells in the ...

    Topic section last updated 03/02/2016 - 11:42am.

  7. Growth Factors

    ... but they do not replace immunosuppressive therapy. Red cell growth factor is called erythropoietin or EPO for short. It is a ... white cell growth factors can increase the growth of blast cells in patients with high-risk MDS. This can be a serious problem. For ...

    Page last updated 01/20/2015 - 4:43pm.

  8. Treating Higher-Risk Myelodysplastic Syndromes

    ... System, which is known as WPSS. IPSS takes into account blast percentage in the bone marrow , any chromosomal abnormalities seen ... of MDS subtypes and whether the patient is dependent on red cell transfusions. In the WPSS, a score of three or above is considered ...

    Interview last updated 05/18/2012 - 1:55pm.

  9. Interviews with the Experts Transplantation & GVHD: What Patients Need to Know

    Why is stem cell transplantation considered a treatment option for many aplastic anemia ... chromosomes that carry a high risk of relapse, or high blast counts, the long-term success is somewhere around 75, maybe 80%. The ...

    Interview last updated 09/30/2014 - 11:07am.

  10. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.

    ... (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We report prospective phase II study results of 29 ... and blasts <10%). Marrow cellularity (P<0.0001) and blast% (P=0.03) were reduced. Toxicities were acceptable, with transient ...

    Research Article last updated 06/28/2013 - 1:30pm.