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  1. Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes

    ... Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment ... two groups (P = 0.500). However, for patients with a high blast count (>5 % of bone marrow at the time of diagnosis), ...

    Research Article last updated 04/16/2014 - 12:24pm.

  2. Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents

    ... was observed in MDS CD34+ cells, whereas stroma/non-blast cellular compartment was positive for PD-1. In a cohort of patients ... resulted in partial demethylation of PD-1 in leukemia cell lines and human samples. This study suggests PD-1 signaling may be ...

    Research Article last updated 12/17/2013 - 8:32am.

  3. Myelodysplastic syndromes in children: where are we today?

    ... and Down syndrome-associated myeloid leukemia.Although the blast count plays a central role in differentiating leukemias from MDSs, it is ... when detected make diagnosis easy. Hematopoietic stem cell transplant is the treatment of choice, while newer agents have shown ...

    Research Article last updated 11/05/2012 - 10:18am.

  4. Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes: Improved outcomes for de novo disease.

    ... Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes : Improved ... p = 0.02). There was no correlation of survival with blast count at diagnosis, IPSS score, cytogenetic abnormality, donor type, or ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. MDS - Treatment (OLD)

    ... change over time. As blood counts go lower and bone marrow blast counts rise, your doctor will discuss other treatment options. ... May or may not need blood transfusions, depending on blood cell counts Have a low or intermediate-1 risk IPSS score, which is between ...

    Topic section last updated 03/10/2016 - 11:01pm.

  6. FAQs

    ... MDS, you must have low blood counts for at least one blood cell type and your blood cells must look abnormal under a microscope. Doctors ... patients being treated for MDS, this might also include no blast cells in the blood and a normal number of blasts cells in the ...

    Topic section last updated 03/02/2016 - 11:42am.

  7. Growth Factors

    ... but they do not replace immunosuppressive therapy. Red cell growth factor is called erythropoietin or EPO for short. It is a ... white cell growth factors can increase the growth of blast cells in patients with high-risk MDS. This can be a serious problem. For ...

    Page last updated 01/20/2015 - 4:43pm.

  8. Treating Higher-Risk Myelodysplastic Syndromes

    ... System, which is known as WPSS. IPSS takes into account blast percentage in the bone marrow , any chromosomal abnormalities seen ... of MDS subtypes and whether the patient is dependent on red cell transfusions. In the WPSS, a score of three or above is considered ...

    Interview last updated 05/18/2012 - 1:55pm.

  9. Interviews with the Experts Transplantation & GVHD: What Patients Need to Know

    Why is stem cell transplantation considered a treatment option for many aplastic anemia ... chromosomes that carry a high risk of relapse, or high blast counts, the long-term success is somewhere around 75, maybe 80%. The ...

    Interview last updated 09/30/2014 - 11:07am.

  10. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.

    ... (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We report prospective phase II study results of 29 ... and blasts <10%). Marrow cellularity (P<0.0001) and blast% (P=0.03) were reduced. Toxicities were acceptable, with transient ...

    Research Article last updated 06/28/2013 - 1:30pm.