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  1. MDS - Treatment (OLD)

    ... change over time. As blood counts go lower and bone marrow blast counts rise, your doctor will discuss other treatment options. ... May or may not need blood transfusions, depending on blood cell counts Have a low or intermediate-1 risk IPSS score, which is between ...

    Topic section last updated 03/10/2016 - 11:01pm.

  2. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... phosphate followed by a donor peripheral stem cell transplant in treating patients with myelodysplastic syndromes ... biliary disease Bone marrow documenting blast count >= 10% or >= 5% in CMML patients who have progressed beyond CMML1 ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.

  3. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... for HLA -Haploidentical hematopoietic stem cell transplant (HSCT) using a reduced intensity conditioning (RIC) ... myelogenous leukemia: all types except refractory blast crisis. Large-cell lymphoma, Hodgkin lymphoma and multiple myeloma ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  4. Selinexor (KPT-330) in Older Patients With Relapsed/Refractory AML (SOPRA)

    ... undergone, and who are not currently eligible for, stem cell transplantation, and are currently deemed unfit for intensive ... Presence of central nervous system (CNS) leukemia. In blast transformation of chronic myeloid leukemia (CML). Prior myelodysplastic ...

    Clinical Trial last updated 08/26/2016 - 9:21am.

  5. RIC Transplant Using Haplo Donors

    ... first-degree relatives utilizing PBSC as the stem cell source. The primary objective of the study is to estimate the incidence of ... in accelerated phase; Chronic myelogenous leukemia with blast crisis that has entered into a second chronic phase following induction ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  6. Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

    ... chemotherapy will improve the response to a stem cell transplant . The safety of this treatment will also be studied. The ... phase or after transformation to accelerated phase or blast crisis. 2 (continued): d. CLL, Lymphoma or Hodgkin's disease which ...

    Clinical Trial last updated 06/06/2016 - 12:41pm.

  7. A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)

    ... testing in patients with MDS and AML. It has decreased the blast count in some patients' blood and bone marrow and has improved ... for potentially curative options such as allogeneic stem cell transplant . No chemotherapy or study drugs for >3 weeks prior to ...

    Clinical Trial last updated 06/03/2016 - 3:09pm.

  8. Dr. Vivienne Rebel reports on a study of the relationship between gene mutations and overall survival after stem cell transplant

    ... with myelodysplastic syndrome after hematopoietic stem-cell transplantation. Original Publication Date:  ... Clinical parameters, such as blast counts and platelet counts, are important indicators of the ...

    Research Review last updated 05/02/2016 - 9:16am.

  9. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... undergoing allogeneic myeloablative (MA) HCT with a T cell depleted graft, the infusion of naturally occurring regulatory T cells ... Chronic myelogenous leukemia (accelerated, blast or second chronic phase) Myelodysplastic syndromes ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  10. Natural Killer (NK) Cells With HLA Compatible Hematopoietic Transplantation for High Risk Myeloid Malignancies

    ... that can be given with chemotherapy and a stem cell transplant to patients with AML and MDS. Researchers want to learn if ... relapse; or (ii) has ever been in accelerated phase or blast crisis. Patient must have an identified a HLA (A,B,C,DR) ...

    Clinical Trial last updated 06/06/2016 - 1:18pm.