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  1. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... syndromes (MDS) is allogeneic hematopoietic stem cell transplantation (alloSCT). As alloSCT confers both a short-term mortality ... of clone size in patients with MDS without increased blast proportion is poorly studied, and it is also not yet known whether ...

    Research Article last updated 04/29/2016 - 10:22am.

  2. Hematopoietic Cell Transplantation for Myelodysplastic Syndromes

    ... Allogeneic hematopoietic cell transplantation (HCT) offers the only potential cure for patients with ... more appropriate for those with lower-risk disease. A high blast burden at the time of HCT increases the risk of subsequent relapse; ...

    Research Article last updated 10/06/2016 - 1:59pm.

  3. Growth Factors

    ... but they do not replace immunosuppressive therapy. Red cell growth factor is called erythropoietin or EPO for short. It is a ... white cell growth factors can increase the growth of blast cells in patients with high-risk MDS. This can be a serious problem. For ...

    Page last updated 01/20/2015 - 4:43pm.

  4. Stem Cell Transplants May Be An Option for Some Elderly MDS Patients

    ... PubMed Abstract:  Allogeneic Stem Cell Transplantations for elderly patients with Myelodysplastic Syndrome ... status of the disease (i.e., advanced status, high blast cell count, the presence of chromosomal abnormalities indicative of ...

    Research Review last updated 05/02/2016 - 9:33am.

  5. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.

    ... (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We report prospective phase II study results of 29 ... and blasts <10%). Marrow cellularity (P<0.0001) and blast% (P=0.03) were reduced. Toxicities were acceptable, with transient ...

    Research Article last updated 06/28/2013 - 1:30pm.

  6. Transplantation Basics

    ... Is it correct to say that stem cell transplantation is a process in which stem cells are gathered from ... chromosomes that carry a high risk of relapse, or high blast counts, the long-term success is somewhere around 75, maybe 80%. The ...

    Interview last updated 04/05/2013 - 2:33pm.

  7. Interviews with the Experts Transplantation & GVHD: What Patients Need to Know

    Why is stem cell transplantation considered a treatment option for many aplastic anemia ... chromosomes that carry a high risk of relapse, or high blast counts, the long-term success is somewhere around 75, maybe 80%. The ...

    Interview last updated 09/30/2014 - 11:07am.

  8. ASH 2012 - Reviewing MDS Progress from Research and Clinical Perspectives

    ... or darbepoetin (Aranesp®) work for low red blood cell counts. Romiplostin can be considered a platelet growth factor ... patients receiving romiplostin seemed to have an increased blast percentage, and some of these patients progressed to leukemia. So the ...

    Interview last updated 02/07/2013 - 1:28pm.

  9. Interviews with the Experts Managing MDS With Supportive Care and Active Treatment

    ... in case of an infection resulting from low white blood cell counts. How are decisions made about using these two different ... they use – including blood counts, bone marrow blast percentage, and bone marrow chromosome (cytogenetic) analysis. With ...

    Interview last updated 09/22/2014 - 12:25pm.

  10. Clinical Trials Report for April 2014

    ... anemia who need treatment for significantly low blood cell counts. National Institutes of Health Clinical Center ... with drugs that suppress the immune system or with stem cell transplant. People with SAA who receive these treatments are more likely ... (CML) in chronic phase, accelerated phase or blast crisis; Acute Myelogenous Leukemia (AML); Myelodysplastic Syndrome (MDS); ...

    Page last updated 04/18/2014 - 3:36pm.