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  1. Hematopoietic Cell Transplantation for Myelodysplastic Syndromes

    ... Allogeneic hematopoietic cell transplantation (HCT) offers the only potential cure for patients with ... more appropriate for those with lower-risk disease. A high blast burden at the time of HCT increases the risk of subsequent relapse; ...

    Research Article last updated 10/06/2016 - 1:59pm.

  2. MDS - Basics

    ... Blast Counts Blasts are very young ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia ...

    Topic section last updated 04/06/2016 - 1:22pm.

  3. Clone of Myelodysplastic Syndromes (MDS)

    ... Blast Counts Blasts are very young or ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia . ...

    Page last updated 04/05/2016 - 3:56pm.

  4. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... syndromes (MDS) is allogeneic hematopoietic stem cell transplantation (alloSCT). As alloSCT confers both a short-term mortality ... of clone size in patients with MDS without increased blast proportion is poorly studied, and it is also not yet known whether ...

    Research Article last updated 04/29/2016 - 10:22am.

  5. Treating Higher-Risk Myelodysplastic Syndromes

    ... System, which is known as WPSS. IPSS takes into account blast percentage in the bone marrow , any chromosomal abnormalities seen ... of MDS subtypes and whether the patient is dependent on red cell transfusions. In the WPSS, a score of three or above is considered ...

    Interview last updated 05/18/2012 - 1:55pm.

  6. Growth Factors

    ... but they do not replace immunosuppressive therapy. Red cell growth factor is called erythropoietin or EPO for short. It is a ... white cell growth factors can increase the growth of blast cells in patients with high-risk MDS. This can be a serious problem. For ...

    Page last updated 01/20/2015 - 4:43pm.

  7. Stem Cell Transplants May Be An Option for Some Elderly MDS Patients

    ... PubMed Abstract:  Allogeneic Stem Cell Transplantations for elderly patients with Myelodysplastic Syndrome ... status of the disease (i.e., advanced status, high blast cell count, the presence of chromosomal abnormalities indicative of ...

    Research Review last updated 05/02/2016 - 9:33am.

  8. Shirley O’Brien’s Remarkable Response in a Clinical Trial

    ... (MDS), a disease that has no cure except for a stem cell transplant . Because I was in my mid-70s, a bone marrow transplant ... and elated. When I’d arrived at MD Anderson, my blast count was at 30%, extremely high and well into to the AML range, which ...

    Patient Chronicle last updated 07/19/2017 - 8:12am.

  9. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.

    ... (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We report prospective phase II study results of 29 ... and blasts <10%). Marrow cellularity (P<0.0001) and blast% (P=0.03) were reduced. Toxicities were acceptable, with transient ...

    Research Article last updated 06/28/2013 - 1:30pm.

  10. Transplantation Basics

    Is it correct to say that stem cell transplantation is a process in which stem cells are gathered from ... chromosomes that carry a high risk of relapse, or high blast counts, the long-term success is somewhere around 75, maybe 80%. The ...

    Interview last updated 04/05/2013 - 2:33pm.