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  1. Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study

    ... chronic myelomonocytic leukaemia ( white blood cell count <13 000/μL), and had anaemia with or without red blood ... in one patient each: myalgia (one [2%]), increased blast cell count (one [2%]), and general physical health deterioration (one ...

    Research Article last updated 09/18/2017 - 1:38pm.

  2. Myelodysplastic syndromes in children: where are we today?

    ... and Down syndrome-associated myeloid leukemia.Although the blast count plays a central role in differentiating leukemias from MDSs, it is ... when detected make diagnosis easy. Hematopoietic stem cell transplant is the treatment of choice, while newer agents have shown ...

    Research Article last updated 11/05/2012 - 10:18am.

  3. Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes

    ... Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment ... two groups (P = 0.500). However, for patients with a high blast count (>5 % of bone marrow at the time of diagnosis), ...

    Research Article last updated 04/16/2014 - 12:24pm.

  4. Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents

    ... was observed in MDS CD34+ cells, whereas stroma/non-blast cellular compartment was positive for PD-1. In a cohort of patients ... resulted in partial demethylation of PD-1 in leukemia cell lines and human samples. This study suggests PD-1 signaling may be ...

    Research Article last updated 12/17/2013 - 8:32am.

  5. Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes: Improved outcomes for de novo disease.

    ... Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes : Improved ... p = 0.02). There was no correlation of survival with blast count at diagnosis, IPSS score, cytogenetic abnormality, donor type, or ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Myelodysplastic Syndromes (MDS)

    ... Blast Counts Blasts are very young or ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia . ...

    Page last updated 02/27/2017 - 7:36am.

  7. Jane Massey’s Story

    ... , hematocrit , and my red and white blood cell count. She ran several tests, and I had a liver biopsy.  After a ... doctors consulted with each other it was determined that my blast count (young, immature white blood cells was better than expected so we ...

    Patient Chronicle last updated 04/11/2017 - 7:29am.

  8. Infectious complications in patients with myelodysplastic syndromes: a review of the literature with emphasis on patients treated with 5-azacitidine

    ... (MDS) are oligo-clonal diseases of the hematopoietic stem cell compartment resulting in peripheral cytopenias and a tendency of ... (IPSS) was the first to include - beside medullary blast count and karyotype - the number of cytopenias and thereby indirectly ...

    Research Article last updated 04/14/2017 - 10:41am.

  9. Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS)

    ... were recruited. h-MDS patients had lower PB white blood cell and blast counts, and lower BM blast percentages, than those with NH-MDS. h-MDS was ...

    Research Article last updated 09/19/2016 - 11:07am.

  10. Acute Myeloid Leukemia (AML)

    ... of every 100 white blood cells in the bone marrow is a blast cell . AML is the most common acute leukemia affecting adults, with about ...

    Topic section last updated 07/07/2016 - 3:15pm.