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  1. Selinexor (KPT-330) in Older Patients With Relapsed/Refractory AML (SOPRA)

    ... undergone, and who are not currently eligible for, stem cell transplantation, and are currently deemed unfit for intensive ... Presence of central nervous system (CNS) leukemia. In blast transformation of chronic myeloid leukemia (CML). Prior myelodysplastic ...

    Clinical Trial last updated 04/17/2018 - 1:51pm.

  2. MDS - Basics

    ... Blast Counts Blasts are very young ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia ...

    Topic section last updated 04/06/2018 - 12:33pm.

  3. Treatments

    ... change over time. As blood counts go lower and bone marrow blast counts rise, your doctor will discuss other treatment options. ... marrow failure diseases to help increase red blood cell , white blood cell or platelet counts. ...

    Topic section last updated 04/06/2018 - 12:30pm.

  4. I Was Alone With MDS Until I Connected With Others on Social Media

    ... (Procrit®) shots for eight weeks because my white blood cell count was so low. I started a regimen of an oral lenalidomide , ... worse. A bone marrow biopsy confirmed our fears, as my blast count exceeded 5%. But my doctor stated that I was still far from ...

    Patient Chronicle last updated 12/13/2017 - 1:57pm.

  5. Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study

    ... chronic myelomonocytic leukaemia ( white blood cell count <13 000/μL), and had anaemia with or without red blood ... in one patient each: myalgia (one [2%]), increased blast cell count (one [2%]), and general physical health deterioration (one ...

    Research Article last updated 09/18/2017 - 1:38pm.

  6. Shirley O’Brien’s Remarkable Response in a Clinical Trial

    ... (MDS), a disease that has no cure except for a stem cell transplant . Because I was in my mid-70s, a bone marrow transplant ... and elated. When I’d arrived at MD Anderson, my blast count was at 30%, extremely high and well into to the AML range, which ...

    Patient Chronicle last updated 07/19/2017 - 8:12am.

  7. Infectious complications in patients with myelodysplastic syndromes: a review of the literature with emphasis on patients treated with 5-azacitidine

    ... (MDS) are oligo-clonal diseases of the hematopoietic stem cell compartment resulting in peripheral cytopenias and a tendency of ... (IPSS) was the first to include - beside medullary blast count and karyotype - the number of cytopenias and thereby indirectly ...

    Research Article last updated 04/14/2017 - 10:41am.

  8. Jane Massey’s Story

    ... , hematocrit , and my red and white blood cell count. She ran several tests, and I had a liver biopsy.  After a ... doctors consulted with each other it was determined that my blast count (young, immature white blood cells was better than expected so we ...

    Patient Chronicle last updated 04/11/2017 - 7:29am.

  9. Myelodysplastic Syndromes (MDS)

    ... Blast Counts Blasts are very young or ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia . ...

    Page last updated 02/27/2017 - 7:36am.

  10. Hematopoietic Cell Transplantation for Myelodysplastic Syndromes

    ... Allogeneic hematopoietic cell transplantation (HCT) offers the only potential cure for patients with ... more appropriate for those with lower-risk disease. A high blast burden at the time of HCT increases the risk of subsequent relapse; ...

    Research Article last updated 10/06/2016 - 1:59pm.